For procurement managers and R&D scientists in the pharmaceutical sector, sourcing high-quality raw materials is paramount. 3,3'-Diiodo-L-Thyronine (CAS 4604-41-5) is one such critical chemical, often sought after for its role as a pharmaceutical intermediate and a vital reference standard. This article aims to guide professionals on how to effectively source this compound, emphasizing the importance of purity, supplier reliability, and understanding market dynamics, particularly when looking to purchase from manufacturers in China.

Understanding the Importance of 3,3'-Diiodo-L-Thyronine

3,3'-Diiodo-L-Thyronine, also known by synonyms such as O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine, is a chemical compound with the CAS number 4604-41-5. Its significance in the pharmaceutical industry stems from its applications as:

  • A Pharmaceutical Intermediate: It serves as a building block in the synthesis of various complex organic molecules, including potential drug candidates. The purity of this intermediate directly impacts the quality of the final pharmaceutical product.
  • A Levothyroxine Impurity Standard: Levothyroxine is a widely used synthetic thyroid hormone. Ensuring the purity of Levothyroxine formulations is critical, and 3,3'-Diiodo-L-Thyronine is recognized as a key impurity standard (Levothyroxine Impurity J) used for quality control and analytical testing.
  • A Reagent in Diagnostic Kits: Its specific chemical properties make it valuable in the development of diagnostic reagents, particularly those related to thyroid hormone metabolism and related assays.

Key Considerations When Purchasing 3,3'-Diiodo-L-Thyronine:

When looking to buy 3,3'-Diiodo-L-Thyronine, several factors should be carefully evaluated to ensure you are obtaining a product that meets your stringent requirements:

  1. Purity Levels: The most crucial aspect is the chemical purity. For pharmaceutical applications and as an impurity standard, exceptionally high purity (e.g., ≥99%) is usually required. Always request a Certificate of Analysis (CoA) detailing the purity, impurity profile, and analytical methods used.
  2. Supplier Reputation and Reliability: Partnering with a reputable manufacturer or supplier is vital. Look for suppliers with a proven track record in producing fine chemicals and pharmaceutical intermediates. Companies based in China have become significant global suppliers, offering competitive pricing and large-scale production capabilities. Understanding their manufacturing standards (e.g., ISO certification) can be beneficial.
  3. CAS Number Verification: Always confirm the CAS number is indeed 4604-41-5 to ensure you are procuring the correct chemical entity.
  4. Packaging and Storage: Proper packaging and recommended storage conditions (e.g., Amber Vial, -20°C Freezer, Under Inert Atmosphere) are critical to maintain the compound's integrity and shelf life.
  5. Price and Quotation: While quality is paramount, competitive pricing is also a significant factor for procurement managers. Requesting quotes for bulk purchases can lead to cost savings.

Navigating the Market for 3,3'-Diiodo-L-Thyronine Suppliers in China

China has a robust chemical manufacturing industry, and many suppliers offer 3,3'-Diiodo-L-Thyronine. When searching for a manufacturer or supplier, consider the following search terms:

  • “buy 3,3'-Diiodo-L-Thyronine CAS 4604-41-5”
  • “O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine supplier China”
  • “pharmaceutical intermediate 4604-41-5 price”
  • “Levothyroxine impurity J manufacturer”
  • “diagnostic reagent 3,3'-Diiodo-L-Thyronine for sale”

Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing high-quality fine chemicals. By engaging with reliable manufacturers, you can ensure a stable supply of essential materials like 3,3'-Diiodo-L-Thyronine, facilitating your research and development processes and ensuring compliance with pharmaceutical standards. For the best price and guaranteed quality, always inquire directly with trusted suppliers.