For procurement managers and R&D scientists in the pharmaceutical sector, sourcing high-quality intermediates is paramount. One such critical compound is 3-(3-Trifluoromethyl-phenyl)-propionaldehyde (CAS 21172-41-8), a key building block, most notably for the synthesis of Cinacalcet. Understanding where to buy this specific chemical and what to look for in a supplier can significantly impact your project's success.

Understanding the Intermediate: Properties and Applications

3-(3-Trifluoromethyl-phenyl)-propionaldehyde is characterized by its unique trifluoromethylphenyl group and an aldehyde functional group. Its molecular formula is C10H9F3O, with a molecular weight of approximately 202.17 g/mol. Typically appearing as a colorless oil, its purity is a critical specification, usually requiring a minimum of 98% for pharmaceutical synthesis. Its primary application lies in its role as an intermediate in the production of Cinacalcet, a vital medication used to manage secondary hyperparathyroidism in patients with chronic kidney disease.

Key Considerations When Sourcing

When looking to purchase 3-(3-Trifluoromethyl-phenyl)-propionaldehyde, several factors should be prioritized:

  • Purity: Always verify the purity specifications. For pharmaceutical intermediates, high purity is non-negotiable to ensure the efficacy and safety of the final drug product.
  • Supplier Reliability: Partner with established manufacturers and suppliers who have a proven track record in chemical production and export. Look for suppliers with robust quality control systems.
  • Manufacturing Capability: Ensure the manufacturer can consistently supply the required quantities, whether for R&D or commercial-scale production. A reliable supply chain is crucial.
  • Regulatory Compliance: Understand that pharmaceutical intermediates must meet certain regulatory standards. While not directly regulated as drugs, their manufacturing processes and documentation are important.
  • Pricing: While quality is paramount, competitive pricing is also a key consideration for procurement managers. Comparing quotes from reputable suppliers can help secure the best value.

Finding a Trusted Manufacturer and Supplier in China

China has emerged as a leading global hub for chemical manufacturing, offering a wide array of intermediates at competitive prices. When seeking a supplier for 3-(3-Trifluoromethyl-phenyl)-propionaldehyde, it is advisable to search for companies that explicitly mention their expertise in pharmaceutical intermediates and fine chemicals. Look for those who provide detailed product specifications, batch analysis reports, and are willing to offer samples for evaluation.

For businesses looking to buy this essential intermediate, exploring options that offer bulk purchasing capabilities with consistent quality control is recommended. A manufacturer that understands the strict requirements of the pharmaceutical industry will be better equipped to meet your needs. Engaging with a supplier who can provide ongoing support, from technical inquiries to timely shipment, will streamline your procurement process. By focusing on these criteria, you can secure a dependable source for 3-(3-Trifluoromethyl-phenyl)-propionaldehyde, facilitating smoother drug development and production cycles.