For procurement managers in the pharmaceutical and fine chemical industries, securing a reliable supply of high-purity chemical intermediates is paramount. One such critical compound is 3-(Trifluoromethyl)phenylpropionic acid, identified by its CAS number 585-50-2. This molecule plays a vital role in various synthetic pathways, most notably as a key intermediate in the production of Cinacalcet, a vital medication used to treat secondary hyperparathyroidism in patients with chronic kidney disease. Understanding its properties, synthesis, and the importance of sourcing from a dependable manufacturer is crucial for efficient operations and product development.

Understanding 3-(Trifluoromethyl)phenylpropionic Acid (CAS 585-50-2)

3-(Trifluoromethyl)phenylpropionic acid is an organic compound characterized by a propionic acid group attached to a phenyl ring substituted with a trifluoromethyl group at the meta position. Its molecular formula is C10H9F3O2, and it typically presents as a white or colorless to yellowish powder, which can also appear as a lumpy solid or clear liquid due to its low melting point of approximately 35°C. This property makes it relatively easy to handle in various chemical processes. Its boiling point is reported around 149°C at 11 mmHg, indicating its stability under moderate conditions.

The presence of the trifluoromethyl (-CF3) group is significant. This electron-withdrawing group imparts unique physicochemical properties, including enhanced lipophilicity and metabolic stability, which are highly desirable in pharmaceutical applications. These characteristics influence how the molecule interacts with biological systems and contribute to the efficacy of the final drug products it helps create.

Key Applications and Market Demand

The primary driver for the market demand for 3-(Trifluoromethyl)phenylpropionic acid is its role as an intermediate in the synthesis of Cinacalcet. Cinacalcet is a calcimimetic agent that works by increasing the sensitivity of the calcium-sensing receptor in the parathyroid gland, thereby helping to regulate calcium levels in the blood. For pharmaceutical companies manufacturing Cinacalcet, a consistent and high-quality supply of this precursor is non-negotiable. As a procurement manager, ensuring access to such intermediates directly impacts production schedules and the availability of life-saving medications.

Beyond pharmaceutical synthesis, 3-(Trifluoromethyl)phenylpropionic acid also finds utility in broader organic synthesis and research. Its reactivity allows it to serve as a versatile building block for creating more complex organic molecules. It can function as a catalyst or co-catalyst in specific chemical transformations, such as boron-catalyzed N-alkylation reactions. This versatility makes it a valuable compound for R&D departments exploring new synthetic routes and novel materials.

Sourcing Strategies: Finding a Reliable Manufacturer and Supplier in China

For procurement managers, identifying a trustworthy manufacturer and supplier is key. China has emerged as a global hub for chemical manufacturing, offering a wide range of intermediates at competitive prices. When looking to buy 3-(Trifluoromethyl)phenylpropionic acid, it's important to partner with suppliers who can guarantee high purity (often specified as ≥98.0% by GC or titration), reliable batch-to-batch consistency, and comprehensive documentation, including Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and Technical Data Sheets (TDS).

When evaluating potential suppliers, consider factors such as their production capacity, adherence to international quality standards (like ISO certifications), and their responsiveness to inquiries. A supplier's willingness to provide samples for quality testing before a bulk purchase is also a critical step in the procurement process. Establishing a strong relationship with a manufacturer ensures not only competitive pricing but also stability in your supply chain, which is vital for uninterrupted production.

Importance of Quality and Purity

In the pharmaceutical industry, the purity of intermediates directly impacts the quality and safety of the final Active Pharmaceutical Ingredient (API). Impurities in 3-(Trifluoromethyl)phenylpropionic acid could lead to unwanted by-products during Cinacalcet synthesis, potentially affecting the drug's efficacy, safety profile, and regulatory approval. Therefore, procurement managers must prioritize suppliers who can demonstrate rigorous quality control and provide detailed analytical data for each batch. Look for suppliers who specify purity levels and methods, such as Gas Chromatography (GC) or titration.

Navigating the Purchase Process

When you are ready to purchase 3-(Trifluoromethyl)phenylpropionic acid, initiating contact with potential manufacturers in China is the first step. Clearly state your requirements, including the CAS number (585-50-2), desired purity, quantity, and any specific packaging needs. Requesting a quotation will allow you to compare pricing structures. Many suppliers offer different price points based on order volume, so inquiring about bulk purchase discounts is advisable. For researchers and smaller operations, inquire about availability in smaller quantities, such as grams or kilograms, to support your R&D efforts.

In summary, 3-(Trifluoromethyl)phenylpropionic acid (CAS 585-50-2) is a critical chemical intermediate with significant applications in pharmaceutical manufacturing and chemical research. By focusing on quality, reliability, and competitive pricing, procurement managers can ensure a stable supply from reputable Chinese manufacturers, thereby supporting the development and production of essential pharmaceuticals and innovative chemical products.