For procurement managers and R&D scientists in the pharmaceutical sector, sourcing critical intermediates like 4-Fluoro-2-methoxy-5-nitroaniline (CAS 1075705-01-9) is a meticulous process. This compound serves as a vital building block in the synthesis of Osimertinib (AZD9291), a significant targeted therapy for certain types of non-small cell lung cancer (NSCLC). Understanding the nuances of procurement can significantly impact project timelines and product quality. This guide aims to demystify the process and highlight what to look for when you need to purchase this essential chemical.

Understanding 4-Fluoro-2-methoxy-5-nitroaniline's Role

As an intermediate, the purity and consistency of 4-Fluoro-2-methoxy-5-nitroaniline are paramount. Its chemical structure and specific functional groups are instrumental in the later stages of Osimertinib synthesis. Any deviation in quality can lead to downstream synthesis issues, affecting the final Active Pharmaceutical Ingredient (API) yield and purity. Therefore, identifying reliable suppliers who can guarantee stringent quality control is the first step for any procurement manager. When you search for a 4-Fluoro-2-methoxy-5-nitroaniline supplier in China, prioritize those with transparent quality certifications and a proven track record.

Key Factors When Buying This Intermediate

When you decide to buy 4-Fluoro-2-methoxy-5-nitroaniline, consider the following:

  • Purity Levels: Look for products with a purity specification of ≥98.0%. This ensures it meets the requirements for pharmaceutical synthesis.
  • CAS Number Verification: Always confirm the CAS number is 1075705-01-9 to ensure you are procuring the correct chemical entity.
  • Supplier Reputation: Choose established manufacturers and suppliers who have experience in providing pharmaceutical intermediates. A good supplier will offer technical support and detailed product documentation, including Certificates of Analysis (CoA).
  • Pricing and Lead Times: When inquiring about CAS 1075705-01-9 price, consider not just the per-kilogram cost but also the reliability of delivery. Long lead times can disrupt critical manufacturing schedules.
  • Regulatory Compliance: Ensure the supplier adheres to international quality and safety standards.

Finding a Reliable Manufacturer and Supplier

The global market offers various sources for this intermediate, but identifying a trustworthy Osimertinib intermediate manufacturer is crucial. Many specialized chemical manufacturers in China excel in producing complex organic intermediates. When you purchase 4-Fluoro-2-methoxy-5-nitroaniline, opting for a direct manufacturer often provides better pricing and more direct communication regarding specifications and custom requirements. Manufacturers can often provide insights into synthesis pathways and quality assurance processes, which is invaluable for R&D scientists.

Procurement Strategy and Next Steps

Developing a robust procurement strategy involves identifying multiple qualified suppliers to ensure supply chain resilience. Companies like NINGBO INNO PHARMCHEM CO., LTD. are dedicated to providing high-quality pharmaceutical intermediates. If you are looking to purchase 4-Fluoro-2-methoxy-5-nitroaniline, we invite you to contact us for a detailed quote and to discuss your specific needs. Leveraging our expertise as a leading supplier in China ensures you receive a quality product at a competitive price, supporting your vital work in drug development.