The pharmaceutical industry constantly seeks high-quality intermediates for developing life-saving drugs. One such critical compound is tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate, identified by CAS number 1628047-84-6. This molecule plays a pivotal role as a key intermediate in the synthesis of ABT-199, also known as Venetoclax, a highly effective BCL-2 inhibitor used in cancer treatment. For researchers and manufacturers, securing a reliable source of this intermediate with exceptional purity is paramount.

Understanding the Importance of Purity for ABT-199 Synthesis

The efficacy and safety of any pharmaceutical end-product are directly linked to the quality of its raw materials. For ABT-199 synthesis, tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate with a purity of 98.0% or higher is often specified. Impurities, even in trace amounts, can lead to complex purification challenges, affect reaction yields, and potentially compromise the final API. Therefore, when looking to buy this compound, prioritizing manufacturers who implement stringent quality control measures is essential. A reputable manufacturer in China will provide detailed Certificates of Analysis (CoA) confirming the purity and specifications of the product.

Applications and Market Outlook for this Key Intermediate

Beyond its primary role in ABT-199 production, tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate serves as a versatile building block in advanced organic synthesis. Its unique chemical structure, featuring a brominated benzoate moiety linked to a pyrrolo[2,3-b]pyridine core, makes it valuable for exploring new drug candidates and developing novel therapeutic agents. The demand for this intermediate is closely tied to the advancements in targeted cancer therapies, where inhibitors like Venetoclax are increasingly important. This suggests a stable and growing market for reliable suppliers.

How to Source Effectively: Finding a Trusted Manufacturer

When sourcing tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate, it's crucial to partner with manufacturers who offer not just competitive pricing but also robust technical support and consistent supply. Look for suppliers who specialize in pharmaceutical intermediates and have a proven track record. Companies emphasizing custom synthesis and contract manufacturing can also be valuable partners, especially for larger-scale production needs. Enquiring about product availability, lead times, and packaging options is standard practice when initiating a purchase.

Conclusion: Securing Your Supply Chain

The successful development and manufacturing of pharmaceuticals like Venetoclax depend heavily on the consistent availability of high-quality intermediates. By understanding the critical purity requirements and diligently seeking out experienced manufacturers and suppliers in regions like China, you can ensure the integrity of your synthesis process and the quality of your final product. For those looking to buy this essential compound, focusing on transparency, quality assurance, and reliable logistics will pave the way for successful procurement.