The advancement of peptide-based therapeutics and research hinges on access to high-quality building blocks. Among these, N-protected amino acids, such as N-Boc-O-benzyl-L-threonine (CAS 15260-10-3), are fundamental. For researchers and procurement specialists, understanding how to source these materials effectively is key to project success. This guide offers insights into finding reliable suppliers and ensuring product quality.

N-Boc-O-benzyl-L-threonine is a specialized derivative of threonine, a naturally occurring amino acid. It is particularly valuable in Boc solid-phase peptide synthesis (Boc SPPS). The tert-butoxycarbonyl (Boc) group protects the alpha-amino group, preventing unwanted reactions during chain elongation. Simultaneously, the benzyl (Bzl) group protects the hydroxyl side chain of threonine. This protection scheme is well-established and allows for controlled peptide assembly and subsequent cleavage.

When looking to buy N-Boc-O-benzyl-L-threonine, researchers often prioritize purity and assay values. Materials with purity levels of 99.00% or higher, as confirmed by analytical techniques like HPLC, are preferred. The appearance, typically a white crystalline powder, is also an important initial quality check. Furthermore, understanding the supplier's manufacturing capabilities and geographical location can influence purchasing decisions. Many global research institutions and pharmaceutical companies choose to source such specialty chemicals from manufacturers in China due to competitive price points and advanced production infrastructure.

A critical aspect of sourcing is engaging with reputable manufacturers and suppliers. These entities provide comprehensive documentation, including Certificates of Analysis (CoA) that detail the product's specifications, such as purity, melting point, and optical rotation. For N-Boc-O-benzyl-L-threonine (CAS 15260-10-3), a typical CoA would confirm its chemical structure, molecular formula (C16H23NO5), and molecular weight (309.36). The specific optical rotation is also a vital parameter for chiral compounds like amino acid derivatives.

Beyond purity, supply chain reliability is paramount. Researchers need assurance that their chosen supplier can consistently deliver the required quantities without delays. This is especially true for ongoing research projects or manufacturing processes. Therefore, inquiring about lead times, minimum order quantities, and packaging options is a standard part of the procurement process.

In conclusion, sourcing high-purity Boc amino acids like N-Boc-O-benzyl-L-threonine requires a diligent approach. By focusing on product specifications, supplier reputation, and supply chain stability, researchers can secure the essential building blocks needed to drive innovation in peptide science and drug discovery. Engaging with leading manufacturers and distributors ensures access to quality materials at competitive prices.