Capecitabine is a widely prescribed oral chemotherapy medication used to treat various cancers, including breast, colorectal, and gastric cancers. Its efficacy relies on its conversion within the body to 5-fluorouracil (5-FU), a potent antimetabolite that interferes with DNA synthesis in cancer cells. The synthesis of Capecitabine is a complex process, and the quality of its pharmaceutical intermediates is paramount to ensure the purity, safety, and efficacy of the final drug product. For manufacturers, identifying reliable suppliers for key intermediates is a critical strategic decision.

The Importance of 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine in Capecitabine Synthesis

Among the critical intermediates in Capecitabine production is 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine (CAS 161599-46-8). This acetylated and fluorinated cytidine derivative serves as a foundational component in creating the Capecitabine molecule. The presence of specific functional groups and the overall stereochemistry are crucial. Therefore, sourcing this intermediate with stringent purity specifications is non-negotiable for pharmaceutical manufacturers aiming for consistent and compliant API production. A high assay value, such as that offered by NINGBO INNO PHARMCHEM CO.,LTD. (≥99.0%), directly translates to a cleaner synthesis and a higher yield of the desired API.

Why Choose a Reputable Manufacturer?

The consequences of using impure or substandard intermediates can be severe, leading to:

  • Compromised API Purity: Impurities can carry through the synthesis, potentially affecting the drug's therapeutic profile.
  • Reduced Yields: Inconsistent quality can lead to lower conversion rates and increased waste.
  • Regulatory Issues: Failing to meet stringent quality standards can result in batch rejection and regulatory non-compliance.
  • Increased Costs: Reworking batches or dealing with product recalls significantly escalates manufacturing costs.

As a leading chemical supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing pharmaceutical intermediates that meet the highest standards. Our commitment to quality control, combined with competitive pricing and efficient supply chain management, makes us a preferred partner for companies looking to buy 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine and other vital intermediates.

Key Considerations When Sourcing

When procuring Capecitabine intermediates, consider the following:

  • Purity Specifications: Always confirm the assay, moisture content, and heavy metal limits.
  • Manufacturing Standards: Ensure the supplier adheres to relevant quality management systems (e.g., ISO, GMP principles for intermediates).
  • Supply Chain Stability: Verify the supplier's capacity to meet your ongoing volume requirements.
  • Technical Documentation: Request comprehensive documentation, including Certificates of Analysis (CoA) and Safety Data Sheets (SDS).

Investing in high-quality pharmaceutical intermediates is an investment in the integrity of your final product and, ultimately, in patient safety. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting your manufacturing needs with reliable, high-purity chemical solutions.