In the highly competitive landscape of pharmaceutical research and development, securing a reliable supply of high-quality chemical intermediates is paramount. For drug developers focused on oncology, particularly those working with targeted therapies like Lenvatinib, sourcing key building blocks such as 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea (CAS: 796848-79-8) is a critical step. This article aims to guide procurement managers, research scientists, and formulation chemists in identifying and sourcing this vital compound effectively.

Understanding 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea
1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea, identified by CAS number 796848-79-8, is recognized as a metabolite of Lenvatinib. Lenvatinib itself is a potent, orally active inhibitor of multiple receptor tyrosine kinases, playing a significant role in cancer treatment. As a metabolite, this intermediate is crucial for in-depth studies concerning Lenvatinib's pharmacokinetic profile, metabolism, and potential impurities, all of which are essential for regulatory submissions and drug efficacy assessments.


Key Considerations for Sourcing
When procuring 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea, several factors must be prioritized to ensure the integrity and success of your research:


  • Purity and Quality: The purity of pharmaceutical intermediates directly impacts the reliability of research outcomes and the safety of potential drug products. Look for suppliers that guarantee high purity levels, often above 98%, and provide detailed Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS).
  • Supplier Reliability: Establishing a relationship with a dependable manufacturer or supplier is crucial. This includes consistent product availability, on-time delivery, and responsive customer support. Given the global supply chain, identifying a supplier with a strong track record and transparent operations is vital.
  • Pricing and Value: While quality is non-negotiable, competitive pricing remains a significant consideration for R&D budgets. Exploring options from established chemical manufacturers, particularly those with extensive production capabilities in regions like China, can offer significant cost advantages without compromising quality.
  • Regulatory Compliance: Ensure that the supplier can provide necessary documentation and adheres to relevant quality standards. For pharmaceutical intermediates, GMP (Good Manufacturing Practice) compliance, even for non-API stages, indicates a commitment to rigorous quality control.

The Advantage of Partnering with China-Based Manufacturers
China has emerged as a global hub for chemical synthesis and manufacturing. For intermediates like 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea, Chinese manufacturers often offer a compelling combination of advanced synthesis capabilities, large-scale production capacity, and competitive pricing. By partnering with reputable Chinese suppliers, pharmaceutical companies can secure a steady and cost-effective supply chain for their critical research materials. It is essential to conduct due diligence, verify supplier credentials, and establish clear communication channels to ensure a smooth procurement process.


Navigating the Purchase Process
For procurement managers and researchers looking to buy 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea, initiating contact with potential suppliers is the first step. Clearly communicate your required quantity, purity specifications, and delivery timelines. Requesting a sample for initial quality assessment is also a standard practice. Understanding the company's manufacturing capacity, commitment to quality control, and ability to provide comprehensive technical documentation will facilitate an informed decision. Leveraging platforms that connect buyers with manufacturers can streamline this process, providing access to a broad spectrum of suppliers who can meet diverse research needs.


In conclusion, sourcing 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea requires a strategic approach that balances quality, reliability, and cost. By understanding the compound's significance and carefully evaluating potential suppliers, research institutions and pharmaceutical companies can ensure they have the essential materials to drive their drug development programs forward. When you need to buy this critical pharmaceutical intermediate, consider established manufacturers in China for consistent quality and value.