For professionals in pharmaceutical research and organic synthesis, securing a reliable supply of high-quality chemical intermediates is paramount. One such crucial compound is 5-Bromo-2,4-difluoroaniline, identified by its CAS number 452-92-6. This article serves as a comprehensive guide for buyers looking to purchase this vital building block, focusing on key factors such as purity, supplier reliability, and market pricing.

Understanding 5-Bromo-2,4-difluoroaniline's Significance

5-Bromo-2,4-difluoroaniline, also known by synonyms like 2,4-Difluoro-5-bromoaniline or 5-Bromo-2,4-difluorobenzenamine, is a fluorinated aromatic amine. Its chemical structure, featuring a bromine atom and two fluorine atoms on an aniline ring, makes it an exceptionally versatile intermediate in various chemical syntheses. Primarily, it is utilized in the pharmaceutical industry as a key component in the creation of active pharmaceutical ingredients (APIs) and in the development of new drug candidates. Its unique reactivity allows for a range of chemical transformations, essential for building complex molecular architectures required for therapeutic efficacy.

The synthesis of 5-Bromo-2,4-difluoroaniline typically involves processes that require precise control over reaction conditions to ensure high purity and yield. Common precursors include nitrobenzene derivatives, which undergo reduction and halogenation steps. For procurement managers and R&D scientists, understanding the synthesis route and the quality control measures employed by a manufacturer can be crucial in ensuring the reliability of the supplied material.

Key Considerations for Buyers

When looking to buy 5-Bromo-2,4-difluoroaniline, several factors should be thoroughly evaluated:

  • Purity and Specifications: Always verify that the product meets your required purity levels (e.g., NLT 98%). Check for adherence to industry standards like USP, BP, or FCC if applicable. Detailed specifications, including appearance (typically an off-white to brown solid), melting point, and molecular formula (C6H4BrF2N), are vital.
  • Supplier Reputation and Reliability: Partnering with established manufacturers and suppliers is key. Look for companies with a proven track record, ISO certifications, and positive customer feedback. For those seeking to purchase in bulk, a consistent supply chain and robust quality management system from a China manufacturer can be a significant advantage.
  • Pricing and Quotation: The price of 5-Bromo-2,4-difluoroaniline can vary based on purity, quantity, and market demand. It is advisable to request quotes from multiple reputable suppliers to ensure competitive pricing. Understanding the pricing structure, including FOB China costs, is essential for budget planning.
  • Technical Support and Documentation: A good supplier will provide comprehensive technical documentation, including Certificates of Analysis (CoA) and Safety Data Sheets (SDS). Access to technical support for application-specific queries can also be invaluable.

Navigating the Procurement Process

The procurement of specialized chemicals like 5-Bromo-2,4-difluoroaniline often involves direct communication with manufacturers or their authorized distributors. Online chemical marketplaces and directories can be excellent starting points for identifying potential suppliers. When contacting a manufacturer, be prepared to provide details about your intended use, required quantities, and delivery timelines. Inquiring about sample availability is also recommended to assess product quality firsthand before committing to a large order.

For businesses aiming to streamline their supply chain, establishing a long-term relationship with a dependable manufacturer of 5-Bromo-2,4-difluoroaniline can lead to better pricing, priority supply, and customized solutions. By focusing on these critical aspects, procurement managers and researchers can confidently source this essential chemical intermediate, driving innovation and success in their respective fields.