For procurement managers and chemical sourcing specialists in the pharmaceutical and biotechnology industries, identifying reliable suppliers for critical peptide synthesis reagents is paramount. Among these, Fmoc-protected amino acids, particularly Fmoc-O-tert-butyl-L-threonine (CAS: 71989-35-0), are indispensable building blocks. This guide aims to equip you with the knowledge to effectively source this vital Fmoc-L-threonine derivative.

Fmoc-O-tert-butyl-L-threonine, or Fmoc-Thr(tBu)-OH, is a fundamental component in Solid Phase Peptide Synthesis (SPPS). Its role is to introduce threonine residues into a growing peptide chain while protecting both its alpha-amino group (with Fmoc) and its side-chain hydroxyl group (with a tert-butyl ester). The tert-butyl protecting group is crucial because it is stable under the conditions used for Fmoc removal but can be easily cleaved during the final acidic cleavage step. This orthogonal protection strategy is key to preventing side reactions and ensuring the fidelity of the synthesized peptide sequence.

When evaluating potential suppliers, several factors are critical. Firstly, purity is non-negotiable. A minimum purity of ≥98% (HPLC) for Fmoc-Thr(tBu)-OH is generally considered the industry standard for reliable SPPS. Higher purity levels translate to fewer impurities in your final peptide product, simplifying downstream purification processes and reducing the risk of failed syntheses. Always ask for Certificates of Analysis (CoA) that detail the purity, identity, and any residual solvents or by-products.

Secondly, consider the manufacturer's experience and capacity. A proven track record in producing amino acid derivatives for peptide synthesis signifies expertise. As a manufacturer and supplier based in China, we pride ourselves on our rigorous quality control systems and our ability to deliver consistent, high-quality Fmoc-O-tert-butyl-L-threonine. We understand that availability and competitive pricing are also key concerns for bulk purchases. Therefore, we strive to offer cost-effective solutions without compromising on quality.

Thirdly, inquire about the application-specific suitability. While Fmoc-Thr(tBu)-OH is standard for SPPS, understanding the supplier’s awareness of current best practices in peptide synthesis—such as solvent compatibility (DMF, NMP, DCM) and coupling reagent efficiency—can be beneficial. We are committed to providing comprehensive product information and support to ensure our Fmoc-L-threonine derivatives meet the evolving needs of peptide chemists.

Choosing the right supplier for your Fmoc-O-tert-butyl-L-threonine is a strategic decision that impacts your research and development timelines and costs. By prioritizing purity, supplier expertise, and consistent supply, you can ensure the success of your peptide synthesis projects. We invite you to explore our range of high-quality peptide synthesis reagents. Contact us today to discuss your needs and obtain a competitive quote for your next batch of Fmoc-Thr(tBu)-OH.