For procurement managers in the pharmaceutical and chemical industries, identifying reliable sources for critical intermediates is paramount. 5-Chlorothiophene-2-carbonyl Chloride (CAS 42518-98-9) stands out as a highly sought-after building block, particularly renowned for its role in the synthesis of anticoagulants like Rivaroxaban. This article delves into why this compound is essential and how to effectively source it from reputable manufacturers.

Understanding 5-Chlorothiophene-2-carbonyl Chloride

Also known by synonyms such as 5-chloro-2-thenoyl chloride, this organosulfur compound features a thiophene ring substituted with a chlorine atom and a reactive carbonyl chloride group. Its molecular formula is C5H2Cl2OS, with a molecular weight of approximately 181.04 g/mol. Typically appearing as a colorless to pale yellow liquid, its boiling point is in the range of 122-127℃ at 16 Torr. Its reactivity stems from the acyl chloride functionality, making it an excellent acylating agent in various organic synthesis reactions.

The Crucial Role in Pharmaceutical Synthesis

The primary application driving demand for 5-Chlorothiophene-2-carbonyl Chloride is its use as a key intermediate in the synthesis of Rivaroxaban. Rivaroxaban, a direct Factor Xa inhibitor, is a widely prescribed anticoagulant used to prevent and treat blood clots. The efficient and cost-effective production of such life-saving medications hinges on the availability of high-quality intermediates like 5-Chlorothiophene-2-carbonyl Chloride. Beyond Rivaroxaban, its unique chemical structure makes it a valuable precursor for a wide array of other pharmaceutical agents, potentially used in antivirals, antifungals, and various other therapeutic areas.

Navigating the Procurement Landscape: Finding a Reliable Supplier

When looking to buy 5-Chlorothiophene-2-carbonyl Chloride, several factors are crucial for procurement managers: purity, consistent supply, and competitive price. Sourcing from China offers significant advantages due to the country's robust chemical manufacturing infrastructure. It is essential to partner with manufacturers who can guarantee high purity levels (often ≥98%) and maintain stringent quality control. Look for suppliers who can provide detailed technical specifications, Certificates of Analysis (CoA), and have a proven track record of reliability.

Key Considerations for Purchasing:

  • Purity Levels: Ensure the product meets the required purity specifications for your downstream synthesis.
  • Supply Chain Stability: Partner with a supplier who can guarantee consistent availability to avoid production disruptions.
  • Pricing: Compare offers from multiple reputable Chinese manufacturers to secure the most competitive price.
  • Technical Support: A knowledgeable supplier can offer valuable insights into handling and application.

By focusing on these aspects, procurement professionals can secure a dependable source for 5-Chlorothiophene-2-carbonyl Chloride, ensuring the efficient and cost-effective production of essential pharmaceuticals. For inquiries regarding purchase, price, or to request a quote from a trusted manufacturer, exploring established chemical suppliers in China is a strategic first step.