The pharmaceutical industry relies on a consistent supply of high-quality intermediates to produce life-saving medications. For manufacturers of the crucial antibiotic Linezolid, sourcing the right precursors is paramount. One such vital compound is (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone, a key intermediate that plays a pivotal role in the synthesis pathway. Understanding its properties and how to procure it effectively is essential for maintaining production efficiency and product integrity.

Understanding (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

This chiral oxazolidinone derivative, identified by CAS number 168828-84-0, is characterized by its off-white to yellow powder appearance. Its precise chemical structure and high purity levels, typically assayed at ≥98.0-102.0%, are critical for its function as a pharmaceutical intermediate. The molecular formula C14H16FN5O3 underscores its complex chemical makeup, requiring specialized synthesis and handling.

The Importance in Linezolid Synthesis

Linezolid is a vital antibiotic used to combat serious infections caused by Gram-positive bacteria, including methicillin-resistant *Staphylococcus aureus* (MRSA). The synthesis of Linezolid is a complex process involving multiple steps, and the quality of each intermediate directly impacts the final product's efficacy and safety. (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone serves as a crucial building block, contributing specific functional groups and stereochemistry necessary for the formation of the active pharmaceutical ingredient (API).

Sourcing Strategies: Manufacturer and Supplier Insights

For pharmaceutical companies looking to buy this intermediate, identifying reliable manufacturers and suppliers is the first step. China has emerged as a significant global hub for chemical manufacturing, offering competitive pricing and a vast production capacity. When searching for a supplier, it's crucial to look for companies that:

  • Demonstrate a strong track record in pharmaceutical intermediate manufacturing.
  • Provide comprehensive Certificates of Analysis (CoA) detailing purity, isomer content, and other critical specifications.
  • Adhere to strict quality control measures and, where applicable, Good Manufacturing Practices (GMP).
  • Offer transparent pricing and reliable lead times for bulk orders.
  • Have robust customer support and technical expertise.

Engaging with a reputable manufacturer or supplier in China for (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone can significantly streamline your procurement process. It's advisable to request quotations for your specific volume requirements and inquire about potential discounts for larger purchases.

Key Considerations for Procurement

Beyond just the price, several factors warrant attention when procuring this intermediate. The price of such specialized chemicals is influenced by synthesis complexity, purity levels, and market demand. Ensuring the supplier can consistently deliver materials that meet your stringent quality requirements is paramount. Additionally, understanding the logistics, including packaging, storage requirements, and shipping, is vital for maintaining the product's integrity until it reaches your facility. For those looking to purchase this critical component, thorough due diligence on potential partners is key to a successful and uninterrupted production cycle.

In conclusion, (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone is an indispensable intermediate for Linezolid synthesis. By partnering with established manufacturers and suppliers, pharmaceutical companies can secure a high-quality, cost-effective supply, thereby ensuring the consistent production of this vital antibiotic. If you are seeking to buy this intermediate, reach out to us for a detailed quote and to learn more about our capabilities as a leading chemical supplier.