In the intricate world of pharmaceutical manufacturing, the sourcing of high-quality intermediates is paramount to ensuring the efficacy and safety of the final drug product. For the production of Losartan, a widely prescribed medication for hypertension, 2-Butyl-4-chloro-5-formylimidazole (CAS 83857-96-9) stands out as a pivotal intermediate. This article aims to guide procurement managers and R&D scientists in understanding this compound and identifying reliable suppliers.

Understanding 2-Butyl-4-chloro-5-formylimidazole: Properties and Significance

2-Butyl-4-chloro-5-formylimidazole is characterized by its pale yellow to light yellow crystalline powder appearance, with a melting point typically between 97-100°C. Its molecular formula is C8H11ClN2O, and its CAS number is 83857-96-9. The compound's chemical structure, featuring an imidazole ring with butyl, chloro, and formyl substituents, makes it exceptionally reactive and suitable for complex organic synthesis pathways. Its primary utility lies in its role as a key intermediate in the synthesis of Angiotensin II receptor blockers (ARBs), with Losartan being the most prominent example. The quality and purity of this intermediate directly impact the quality of the final Active Pharmaceutical Ingredient (API).

Why is Sourcing Crucial for Your Business?

For pharmaceutical companies, the procurement of 2-Butyl-4-chloro-5-formylimidazole is not just a transaction but a strategic decision. A consistent supply of high-purity material is essential for uninterrupted production and regulatory compliance. Working with reputable manufacturers and suppliers ensures that the intermediate meets stringent quality standards, minimizing risks of batch failures or regulatory hurdles. Sourcing from established players in China, such as NINGBO INNO PHARMCHEM CO., LTD., can offer cost advantages and access to advanced manufacturing capabilities.

Key Considerations When Buying

When looking to buy 2-Butyl-4-chloro-5-formylimidazole, consider the following factors:

  • Purity: Look for suppliers who can guarantee a high assay, typically 99% or more, with detailed certificates of analysis (COA).
  • Manufacturing Capacity: Ensure the manufacturer has the capacity to meet your projected demand, especially for large-scale production.
  • Regulatory Compliance: Verify that the supplier adheres to international quality standards and can provide necessary documentation like MSDS and potentially GMP certifications if required.
  • Supply Chain Reliability: A robust supply chain with efficient logistics is critical for on-time delivery and avoiding production delays.
  • Price: While quality is paramount, competitive pricing from a reliable manufacturer can significantly impact your product's cost-effectiveness.

Finding a Reliable Manufacturer and Supplier

Identifying a trustworthy manufacturer for 2-Butyl-4-chloro-5-formylimidazole is crucial. Companies specializing in pharmaceutical intermediates, with a strong track record and positive customer testimonials, are ideal partners. For procurement managers seeking to purchase this vital component, exploring options from established Chinese chemical manufacturers like NINGBO INNO PHARMCHEM CO., LTD. can provide access to high-quality products at competitive prices. We are dedicated to providing our clients with the best possible solutions, ensuring they receive the precise specifications required for their critical applications. Contact us today to inquire about purchasing and to receive a quote for your needs.

Investing in a reliable source for 2-Butyl-4-chloro-5-formylimidazole is an investment in the quality and success of your pharmaceutical products. We invite you to explore our offerings and discover the difference that expertise and commitment make.