For professionals in the pharmaceutical industry, sourcing reliable and high-purity ingredients is paramount. Mannitol, identified by CAS number 87-78-5, is a versatile sugar alcohol that plays a critical role in various drug formulations. Its unique properties as an osmotic diuretic and excipient make it indispensable for specific therapeutic applications.

Mannitol is a white, crystalline powder, often described as odorless and possessing a mildly sweet taste. Chemically, it's a polyol, C6H14O6, naturally occurring in many fruits and vegetables, but commercially significant when produced from corn starch. Its key characteristic, especially for pharmaceutical manufacturers, is its osmotic activity. When administered intravenously, it is filtered by the kidneys and not reabsorbed, leading to increased urine output. This makes it invaluable for reducing elevated intracranial pressure (ICP) and intraocular pressure (IOP), conditions often associated with brain edema and glaucoma, respectively.

Beyond its diuretic properties, Mannitol serves as an excellent pharmaceutical excipient. Its inert nature, good compressibility, and sweet taste make it suitable for use in tablet formulations, acting as a diluent, binder, and sweetener. This dual functionality allows for cost-effective and high-quality drug development.

When looking to buy Mannitol, it’s crucial to partner with a reputable manufacturer or supplier. Prioritize suppliers who can provide detailed specifications, including purity levels (e.g., 98% or higher for pharmaceutical grade), molecular structure, and CAS confirmation. Understanding the production process, whether it’s from natural extraction or chemical synthesis, can also be beneficial. For procurement managers, ensuring a stable supply chain and competitive pricing is key to managing manufacturing costs effectively. Many buyers opt to purchase Mannitol in bulk from trusted manufacturers in regions like China, known for their robust chemical production capabilities.

The careful selection of a Mannitol supplier directly impacts the quality and safety of the final pharmaceutical product. Therefore, due diligence in verifying quality certifications (like ISO) and consistent batch quality is essential. By securing a reliable source for Mannitol, pharmaceutical companies can ensure the efficacy and safety of their life-saving medications.