In the pharmaceutical industry, sourcing reliable and high-purity raw materials is paramount. N-Acetyl-L-cysteine, commonly known as NAC, with CAS number 616-91-1, is one such compound that plays a critical role in various therapeutic applications. For procurement managers and R&D scientists, understanding its properties and identifying dependable suppliers is key to ensuring product quality and manufacturing efficiency. This guide will delve into NAC, its uses, and what to look for when you decide to buy this essential pharmaceutical intermediate.

N-Acetyl-L-cysteine (C5H9NO3S) is a derivative of the amino acid cysteine. It typically appears as white crystals or a crystalline powder and has a molecular weight of 163.20. Its significant therapeutic benefits stem from its ability to replenish intracellular glutathione, a potent antioxidant, and its mucolytic properties.

Key Pharmaceutical Applications of NAC

NAC is widely recognized for its dual action in medicine:

  • Mucolytic Agent: NAC is a cornerstone in treating respiratory conditions characterized by excessive and thick mucus. It works by breaking disulfide bonds in mucoproteins, thereby reducing the viscosity of mucus. This makes it easier for patients to expel secretions, a crucial aspect for those suffering from conditions like bronchitis, cystic fibrosis, and COPD. When you purchase NAC for these applications, you are investing in effective airway clearance therapies.
  • Antidote for Acetaminophen Poisoning: Perhaps one of its most critical applications is as an antidote for acetaminophen (paracetamol) overdose. Acetaminophen, when taken in excess, can cause severe liver damage by depleting glutathione stores. NAC replenishes these stores and directly conjugates with the toxic metabolite of acetaminophen, preventing hepatocellular injury. This life-saving role makes a consistent supply of high-purity NAC indispensable for hospitals and pharmaceutical manufacturers.

What to Consider When Purchasing NAC

When seeking to buy N-Acetyl-L-cysteine, several factors are critical for procurement professionals:

  • Purity and Specifications: Ensure the product meets stringent pharmaceutical standards, with an assay typically between 98.5-101.0%. Pay attention to specifications like heavy metals content (≤10ppm) and loss on drying (≤0.50%). These parameters are vital for product efficacy and safety.
  • Supplier Reliability: Partnering with an established manufacturer and supplier in China ensures a stable supply chain, competitive pricing, and consistent quality. Look for suppliers who can provide comprehensive documentation and adhere to international quality standards.
  • Packaging and Storage: Proper packaging, such as 25kg fiber drums, and storage in dark, dry, and ventilated areas away from sunlight and oxidants are crucial for maintaining product integrity.
  • Regulatory Compliance: Verify that the supplier adheres to relevant pharmaceutical manufacturing regulations and can provide necessary certifications.

For businesses looking to secure a reliable source of N-Acetyl-L-cysteine, identifying reputable manufacturers and suppliers is the first step. By focusing on product quality, supplier reliability, and application-specific needs, pharmaceutical companies can confidently integrate NAC into their product lines. We are committed to being your trusted partner, offering high-quality NAC with dependable service to support your critical pharmaceutical manufacturing goals.