For procurement managers and R&D scientists in the pharmaceutical and biotech sectors, securing a reliable supply of high-quality intermediates is paramount. N-Cbz-L-Phenylalanine (CAS 1161-13-3) is one such critical compound, widely utilized in peptide synthesis and as a building block for active pharmaceutical ingredients (APIs). This article aims to guide prospective buyers on how to effectively source this fine chemical, focusing on key considerations when partnering with manufacturers, particularly those based in China.

Understanding N-Cbz-L-Phenylalanine: The Basics

N-Cbz-L-Phenylalanine, also known by synonyms like Z-Phe-OH or Carbobenzoxyphenylalanine, is an N-protected derivative of the amino acid L-phenylalanine. Its chemical formula is C17H17NO4 and it typically appears as a white to off-white powder. Its primary roles in research and manufacturing include acting as a substrate in peptide synthesis, where the carbobenzyloxy (Cbz) group serves as a protective moiety, and as an inhibitor for certain proteases like thermolysin. For anyone looking to buy N-Cbz-L-Phenylalanine, understanding its purity and form is essential.

Key Considerations for Buyers

When engaging with potential suppliers for N-Cbz-L-Phenylalanine, several factors should be carefully evaluated to ensure a successful procurement process and a reliable supply chain:

  • Purity and Quality Assurance: Manufacturers should provide detailed Certificates of Analysis (CoA) that specify the purity of the compound (often >95% or >98%). For pharmaceutical applications, consistent batch-to-batch quality is non-negotiable. Look for manufacturers who adhere to international quality standards.
  • Manufacturing Capabilities and Scale: Confirm that the manufacturer has the capacity to meet your required order volumes, whether it's for lab-scale research or larger industrial production. A reputable N-Cbz-L-Phenylalanine manufacturer China will have scalable production facilities.
  • Pricing and Payment Terms: Competitive pricing is a significant factor, especially for bulk purchases. However, it should not compromise quality. Understanding payment terms like L/C, T/T, or others offered by the supplier is crucial for financial planning. Inquire about N-Cbz-L-Phenylalanine price early in your search.
  • Supply Chain Reliability and Logistics: A stable supply chain is vital. Investigate the supplier's lead times, packaging capabilities, and shipping options (Ocean, Land, Air, DHL, TNT). For international buyers, understanding Incoterms (FOB, CFR, CIF, EXW) is also important. A good N-Cbz-L-Phenylalanine supplier will have a well-established logistics network.
  • Technical Support and Documentation: Access to technical support and comprehensive product documentation, including MSDS and application notes, can be invaluable. Manufacturers who can provide detailed information about their CAS 1161-13-3 pharmaceutical intermediate offerings foster trust.

Partnering with Chinese Manufacturers

China has emerged as a dominant global supplier of fine chemicals and pharmaceutical intermediates. For N-Cbz-L-Phenylalanine, sourcing from China can offer significant cost advantages and access to a vast production network. However, it is imperative to vet suppliers thoroughly. Look for manufacturers with a proven track record, good communication channels, and a commitment to quality. Companies that can provide comprehensive product information and efficient customer service are ideal partners.

Making the Purchase Decision

When you decide to purchase N-Cbz-L-Phenylalanine, thorough due diligence on the manufacturer is key. Consider requesting samples to verify quality before placing a large order. Engaging directly with a manufacturer, rather than intermediaries, often leads to better pricing and more direct communication, ensuring you get the best value and support for your research and manufacturing needs.

By focusing on these critical aspects, procurement professionals can confidently source N-Cbz-L-Phenylalanine, ensuring the success of their pharmaceutical development and chemical synthesis projects. Remember to always prioritize quality and reliability when selecting your chemical supplier.