In the demanding field of pharmaceutical manufacturing, the procurement of high-quality intermediates is as critical as the final Active Pharmaceutical Ingredient (API) itself. For companies involved in the production or research of Paclitaxel, a cornerstone in cancer therapy, sourcing reliable precursors like (4S,5R)-3-Benzoyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid is paramount. This article aims to guide procurement managers through the essential considerations when identifying and partnering with a suitable manufacturer and supplier.

Understanding the Product: (4S,5R)-3-Benzoyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

This specific oxazolidine derivative is a key chiral building block. Its precise stereochemistry, denoted by (4S,5R), is non-negotiable for its efficacy as an intermediate in the semi-synthesis of Paclitaxel. The compound's molecular structure provides the foundational elements that are further modified in subsequent synthesis steps. When inquiring about this product, always look for the CAS number 153652-70-1 to ensure you are referencing the correct chemical entity.

Key Procurement Considerations for Buyers:

  • Purity and Assay: The article highlights a purity of ≥98.0%. For pharmaceutical applications, consistently meeting or exceeding this purity level is essential to prevent unwanted side reactions, improve yields, and ensure the safety and efficacy of the final drug product. Always request detailed Certificates of Analysis (CoA) for each batch.
  • Stereochemical Integrity: Given its role as a chiral intermediate, verifying the correct enantiomeric or diastereomeric purity is crucial. Manufacturers should provide detailed spectroscopic data, such as NMR, that confirms the specified stereochemistry.
  • Manufacturing Capacity and Reliability: For commercial production, a supplier's manufacturing capacity and their track record for consistent delivery are vital. It’s advisable to assess the supplier's infrastructure, quality management systems (e.g., ISO certification), and their ability to scale up production without compromising quality. Establishing a partnership with a manufacturer in China can offer cost benefits, but due diligence is key.
  • Regulatory Compliance: While this compound is an intermediate, understanding the supplier's adherence to Good Manufacturing Practices (GMP) principles or similar quality standards can provide an added layer of confidence. Inquire about their documentation and traceability processes.
  • Pricing and Quotation: When seeking a price for this pharmaceutical intermediate, be prepared to discuss your required quantity (from R&D scale to bulk orders) and delivery timelines. Request detailed quotations that outline product price, pack size options, and shipping terms. Building a long-term relationship with a supplier often leads to better pricing and more favorable terms over time.

Why Partner with a Dedicated Manufacturer?

As a dedicated manufacturer of specialized organic compounds, we understand the unique demands of the pharmaceutical industry. By sourcing directly from us, you benefit from competitive pricing, direct quality control, and a streamlined supply chain. We are committed to being your reliable partner, ensuring you can buy high-purity (4S,5R)-3-Benzoyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid with confidence. Our expertise in producing advanced intermediates means you can focus on your core mission: developing life-saving therapies. We invite you to submit an inquiry to receive a detailed quotation and explore how our offerings can support your procurement needs.