For procurement managers in the pharmaceutical sector, securing a reliable supply of high-quality intermediates is paramount. One such critical intermediate is 5-Amino-2-methylbenzenesulfonamide (CAS 6973-09-7), a cornerstone in the synthesis of Pazopanib, a vital anti-cancer medication. This article aims to guide procurement professionals in identifying and sourcing this essential compound effectively.

Understanding the Intermediate's Significance

5-Amino-2-methylbenzenesulfonamide plays a crucial role in the multi-step synthesis of Pazopanib, an active pharmaceutical ingredient (API) used to treat advanced renal cell carcinoma and advanced soft tissue sarcoma. The purity and consistency of this intermediate directly impact the yield and quality of the final API. Therefore, understanding its specifications, such as its typical appearance as an off-white to white crystalline powder and a minimum purity of 98.0%, is vital for any buyer.

Key Factors for Sourcing

When evaluating suppliers for 5-Amino-2-methylbenzenesulfonamide, several factors should be considered:

  • Supplier Reputation and Reliability: Look for manufacturers with a proven track record in producing pharmaceutical intermediates. A reputable supplier will have robust quality control systems and a consistent supply chain. Consider suppliers who can provide comprehensive documentation, such as Certificates of Analysis (CoA).
  • Product Quality and Specifications: Ensure the supplier can consistently meet the required purity levels (≥98.0%) and physical specifications. Understanding the material's stability and proper storage conditions (e.g., storing in a cool, ventilated place) is also important.
  • Manufacturing Capabilities and Compliance: As a pharmaceutical intermediate, compliance with relevant industry standards is essential. Suppliers adhering to Good Manufacturing Practices (GMP) or similar quality management systems are often preferred.
  • Pricing and Commercial Terms: While quality is paramount, competitive pricing is a significant factor for procurement. Engaging with manufacturers directly, especially those based in China, can offer cost advantages. Inquire about bulk purchase discounts and flexible payment terms.
  • Logistics and Packaging: Proper packaging (e.g., 25 kg drums) and secure logistics are crucial to maintain product integrity during transit. Understand the supplier's shipping capabilities and lead times.

Navigating the Market: Finding a Manufacturer

Identifying the right manufacturer for 5-Amino-2-methylbenzenesulfonamide involves thorough market research. Online platforms and industry directories can help you find potential suppliers. When you find a promising manufacturer, initiate contact to request detailed product information, including specifications, pricing, and lead times. Asking for samples for in-house testing is a standard practice to verify quality before committing to larger orders. Building a strong relationship with a reliable manufacturer or supplier can streamline your procurement process and ensure uninterrupted production of critical medicines like Pazopanib.

For procurement managers seeking a dependable source of 5-Amino-2-methylbenzenesulfonamide, focusing on quality, supplier reliability, and competitive pricing will lead to successful sourcing. We, as a dedicated supplier in China, are committed to meeting these requirements, offering high-purity intermediates to support your pharmaceutical manufacturing goals. Contact us today to buy or to request a quote for your Pazopanib intermediate needs.