Navigating the complex world of pharmaceutical manufacturing requires access to high-quality raw materials and intermediates. For companies involved in developing advanced therapeutics, particularly those targeting cancer, understanding critical compounds like 13-Acetyl-9-dihydrobaccatin III (CAS 142203-65-4) is paramount. This article aims to guide procurement managers and research scientists in sourcing this essential pharmaceutical intermediate, highlighting its significance and what to look for in a reliable supplier.

Understanding 13-Acetyl-9-dihydrobaccatin III

13-Acetyl-9-dihydrobaccatin III, identified by its CAS number 142203-65-4, is a vital component in the synthesis of certain taxane-based chemotherapy drugs. Taxanes are a class of highly effective anti-cancer agents, and their complex structures necessitate specialized intermediate compounds for efficient and pure synthesis. As a white powder with a high purity level (often 98% or more), this intermediate plays a crucial role in ensuring the efficacy and safety of the final drug product.

Why is Sourcing Critical?

The pharmaceutical industry operates under strict regulations, demanding unparalleled consistency and purity from its raw materials. For 13-Acetyl-9-dihydrobaccatin III, key considerations for procurement include:

  • Purity and Specifications: Ensure the intermediate meets the required purity standards and specifications, such as those outlined by pharmacopoeias or internal quality control.
  • Manufacturing Consistency: A reputable manufacturer will demonstrate consistent batch-to-batch quality, which is essential for reproducible drug synthesis.
  • Supply Chain Reliability: For ongoing production, securing a stable supply from a dependable supplier is non-negotiable. This involves looking at their production capacity and logistics.
  • Regulatory Compliance: The manufacturer should adhere to relevant quality management systems, such as GMP, where applicable, for pharmaceutical intermediates.

Finding a Trusted Manufacturer and Supplier

When looking to buy 13-Acetyl-9-dihydrobaccatin III, partnering with an experienced manufacturer and supplier is key. Manufacturers based in China, for instance, often offer competitive pricing while maintaining high quality standards. When evaluating potential suppliers, consider:

  • Manufacturer's Reputation: Look for established companies with a proven track record in producing pharmaceutical intermediates.
  • Technical Data and Support: Access to detailed Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and responsive technical support can significantly aid in the procurement process.
  • Pricing and Bulk Discounts: Obtain quotes for both sample quantities and bulk orders to understand the overall cost-effectiveness. A good supplier will offer transparent pricing.
  • Global Reach: For international buyers, a supplier's ability to manage international shipping and export documentation is crucial.

By focusing on these aspects, pharmaceutical companies can ensure they are sourcing 13-Acetyl-9-dihydrobaccatin III from a reliable partner, thereby contributing to the successful development and production of life-saving medications. If you are seeking to purchase this critical intermediate, engaging with established manufacturers in China can provide both quality and cost advantages.