For research and development managers in the pharmaceutical sector, the reliable sourcing of high-quality chemical intermediates is paramount. These specialized compounds serve as the foundational building blocks for synthesizing complex drug molecules and active pharmaceutical ingredients (APIs). One such crucial intermediate is 4-Chloro-5H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile (CAS: 1004991-91-6). Understanding its properties and how to procure it effectively can significantly impact project timelines and success rates.

Understanding the Intermediate: Properties and Applications

4-Chloro-5H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile is a white powder with a high purity level, typically exceeding 99.0%. Its molecular formula is C6H2ClN5. This compound is primarily recognized for its role as a medical intermediate, essential for the synthesis of a variety of pharmaceutical drugs and biologically active molecules. Its specific chemical structure makes it a valuable precursor in multi-step organic synthesis pathways that lead to novel therapeutics.

When considering the purchase of such a critical material, R&D managers often look for suppliers that can guarantee consistent quality and reliable availability. The need for a stable supply chain for intermediates like this is a constant concern for ensuring uninterrupted production and research activities. Therefore, identifying a trusted manufacturer or supplier becomes a strategic imperative.

Key Considerations When Buying Intermediates

When you decide to buy 4-Chloro-5H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile, several factors should guide your decision-making process. Firstly, the purity specification is non-negotiable. For pharmaceutical applications, even minor impurities can have significant consequences on the efficacy and safety of the final drug product. Secondly, the origin of the chemical is important; sourcing from established chemical hubs like China can offer competitive pricing, but due diligence on supplier reliability is essential.

Look for suppliers who can provide comprehensive technical data sheets (TDS) and material safety data sheets (MSDS). These documents offer critical information on the chemical's properties, handling procedures, storage recommendations, and safety precautions. For instance, understanding that the product is a white powder and how it should be stored (e.g., in a cool, airy place, away from fire and heat) is vital for maintaining its integrity.

Finding a Reliable Supplier and Obtaining a Quote

Navigating the market to find the best chemical suppliers can be a challenge. When searching for a “pharmaceutical intermediate supplier China” or seeking a specific CAS number like 1004991-91-6, it's beneficial to engage with companies that demonstrate a strong commitment to quality and customer service. Many reputable manufacturers offer online platforms where you can easily request a quote or inquire about bulk purchases. This direct communication channel with a manufacturer ensures you get the most accurate pricing and availability information.

Furthermore, established chemical suppliers often have robust quality management systems, such as ISO certifications, which further attest to their reliability. Choosing a supplier that understands the rigorous demands of the pharmaceutical industry is key. They should be able to provide consistent product quality, timely delivery, and responsive support. By focusing on these aspects, R&D managers can secure the necessary intermediates to drive their innovative projects forward, ensuring efficient and successful drug development.