For pharmaceutical companies and contract research organizations (CROs), securing a consistent and high-quality supply of key intermediates is paramount. Rosuvastatin Ethyl Ester (CAS 851443-04-4) is one such critical compound, serving as a vital building block in the synthesis of Rosuvastatin, a widely prescribed medication for managing hyperlipidemia and reducing cardiovascular risk.

Understanding the nuances of sourcing this pharmaceutical intermediate can significantly impact production timelines, costs, and ultimately, product quality. This guide aims to equip procurement managers and R&D scientists with the essential knowledge needed to identify and engage with reputable Rosuvastatin Ethyl Ester manufacturers and suppliers, particularly those based in China, a global hub for chemical production.

What is Rosuvastatin Ethyl Ester?

Rosuvastatin Ethyl Ester is a chemical compound with the molecular formula C24H32FN3O6S and CAS number 851443-04-4. It is recognized as a key intermediate in the synthetic pathway leading to Rosuvastatin Calcium, the active pharmaceutical ingredient (API) found in many popular cholesterol-lowering drugs. Its precise chemical structure and high purity are essential for downstream reactions to proceed efficiently and yield the desired final product.

Key Considerations for Procurement:

When looking to buy Rosuvastatin Ethyl Ester, several factors must be carefully evaluated:

  1. Purity and Quality Standards: For pharmaceutical applications, exceptionally high purity is non-negotiable. Look for suppliers who guarantee a purity of ≥99% and provide comprehensive Certificates of Analysis (CoA) detailing analytical data such as HPLC, NMR, and mass spectrometry. Adherence to pharmacopoeial standards is also a significant advantage.
  2. Manufacturer Reputation and Reliability: Partnering with established manufacturers with a proven track record is crucial. Consider suppliers who have robust quality management systems, such as ISO certifications, and a transparent supply chain. A reliable manufacturer ensures consistent product availability, mitigating the risk of production delays.
  3. Pricing and Cost-Effectiveness: While quality is paramount, competitive pricing is a key driver for procurement managers. Sourcing from China often offers cost advantages due to economies of scale and efficient manufacturing processes. However, always balance cost with guaranteed quality and reliability.
  4. Supply Chain Stability: A stable and resilient supply chain is vital, especially for critical intermediates. Investigate the supplier's production capacity, inventory management, and logistics capabilities to ensure they can meet your ongoing demand.
  5. Regulatory Compliance: Ensure the supplier can provide all necessary documentation and support for regulatory submissions, such as Drug Master Files (DMFs) or Certificates of Suitability (CEPs), if applicable to your product's market.

Where to Buy Rosuvastatin Ethyl Ester

China is a leading global supplier of pharmaceutical intermediates. When seeking a manufacturer or supplier, look for companies that specialize in fine chemicals and pharmaceutical raw materials. Companies that offer a wide range of pharmaceutical intermediates and have established export channels are often well-equipped to serve international clients. Engaging directly with a reputable manufacturer in China can often provide direct access to the best pricing and technical support. For those seeking to purchase in smaller quantities for research or development, specialized chemical suppliers also offer Rosuvastatin Ethyl Ester, often with fast delivery options.

Navigating the Purchase Process

The process of purchasing Rosuvastatin Ethyl Ester typically involves requesting a quotation, reviewing the supplier's specifications and CoA, negotiating terms, and arranging payment and shipping. Clear communication throughout this process is key. Potential buyers should be prepared to provide details about their intended use, required quantities, and delivery timelines.

In conclusion, sourcing Rosuvastatin Ethyl Ester requires a strategic approach that prioritizes quality, reliability, and cost-effectiveness. By carefully selecting a trusted manufacturer or supplier, pharmaceutical companies can ensure a seamless procurement process for this essential intermediate, ultimately contributing to the successful production of life-saving medications.