For pharmaceutical manufacturers involved in the synthesis of targeted cancer therapies, the reliable sourcing of high-quality intermediates is paramount. One such critical compound is the precursor for Rucaparib, a potent PARP inhibitor. This article aims to guide procurement managers and R&D scientists in identifying and securing the necessary intermediates, specifically focusing on the role and procurement of 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde (CAS: 283173-84-2).

Rucaparib, a significant player in the oncology treatment landscape, requires meticulously synthesized intermediates to ensure the efficacy and safety of the final Active Pharmaceutical Ingredient (API). The intermediate 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde is a cornerstone in its manufacturing process. Its chemical structure, featuring a fluorinated azepinoindolone core, is crucial for building the complex molecular architecture of Rucaparib.

When sourcing this vital intermediate, pharmaceutical companies must prioritize purity and consistency. A typical specification for this compound is ≥99.0% HPLC purity, ensuring minimal impurities that could affect subsequent reaction steps or the final drug product. Understanding the molecular formula (C18H13FN2O2) and molecular weight (308.30600) is fundamental for accurate stoichiometric calculations in synthesis planning. As a leading manufacturer and supplier from China, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes these critical quality parameters, offering this intermediate in standard packaging like 25 kg drums, with flexibility for custom packaging solutions.

Procurement managers often seek to buy 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde from reputable sources that can guarantee not only quality but also a stable supply chain. Identifying a reliable 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde supplier is key to maintaining uninterrupted production schedules. Factors such as competitive Rucaparib intermediate chemical price, efficient logistics, and responsive customer service are important considerations. Companies looking to secure this compound should engage with manufacturers who have a proven track record in producing high-purity pharmaceutical intermediates.

For those involved in drug discovery and development, understanding the applications of this intermediate is also crucial. Beyond its direct use in Rucaparib synthesis, this fluorinated benzaldehyde derivative can serve as a valuable building block for other novel therapeutic agents. Exploring different suppliers and obtaining price quotes for various quantities, from grams for research to kilograms for commercial production, is a standard practice. When you purchase 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde, ensure the supplier can provide necessary documentation, such as Certificates of Analysis (CoA), to verify product specifications.

In conclusion, securing a dependable source for high-quality Rucaparib intermediates like 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde is vital for pharmaceutical manufacturers. By focusing on purity, supplier reliability, and competitive pricing, companies can ensure the successful and efficient production of life-saving medications. We invite you to explore our offerings as a premier manufacturer and supplier of this essential pharmaceutical building block.