Navigating the procurement of specialized chemical intermediates can be a complex task for R&D scientists and procurement managers. (S)-(+)-1-Boc-3-hydroxypyrrolidine (CAS 101469-92-5) is one such compound, frequently sought after for its critical role in advanced organic synthesis, particularly within the pharmaceutical sector. When looking to buy this essential building block, understanding its properties, applications, and how to secure a dependable supply is paramount.

Understanding (S)-(+)-1-Boc-3-hydroxypyrrolidine: Properties and Applications

This chiral compound, characterized by its white crystalline powder appearance, is chemically known as tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate. Its molecular formula is C9H17NO3, with a molecular weight of 187.24. The significance of (S)-(+)-1-Boc-3-hydroxypyrrolidine lies in its application as a key intermediate. It is integral to the synthesis of ligands for acetylcholine receptors, making it invaluable for research into neurological disorders and potentially cancer treatments. Its use extends to various facets of organic synthesis, where stereospecificity is crucial for the efficacy of the final product. For researchers and formulators, sourcing a compound with guaranteed purity (often specified as ≥99%) is non-negotiable to ensure reproducible results and the integrity of their synthetic pathways.

Key Considerations When Purchasing

For procurement managers and research scientists, the decision to purchase (S)-(+)-1-Boc-3-hydroxypyrrolidine involves several critical factors. Firstly, the purity and enantiomeric excess (ee) of the material are paramount. Reputable manufacturers will provide detailed Certificates of Analysis (CoA) specifying these parameters. Secondly, understanding the potential applications, such as its role as a pharmaceutical intermediate or in the synthesis of specific receptor ligands, helps in aligning the supplier's product quality with project requirements. Thirdly, the reliability of the supplier is a major consideration. Businesses look for manufacturers and suppliers who can guarantee consistent supply, competitive pricing, and robust logistical support, especially when sourcing from international markets like China.

Finding a Reliable Manufacturer and Supplier

When seeking to buy (S)-(+)-1-Boc-3-hydroxypyrrolidine, it is advisable to partner with established chemical manufacturers or distributors. Many leading chemical suppliers offer this intermediate, often with detailed product specifications, safety data sheets (SDS), and technical support. Engaging with suppliers based in China can often provide cost advantages without compromising on quality, provided due diligence is performed. Look for suppliers who clearly state their manufacturing capabilities, quality control processes, and ability to provide necessary documentation. For example, seeking out a dedicated manufacturer in China specializing in pharmaceutical intermediates can ensure you get the best price and quality for your bulk requirements. Always inquire about sample availability for initial evaluation and establish clear communication channels for any technical queries or order updates.

In conclusion, securing a high-quality supply of (S)-(+)-1-Boc-3-hydroxypyrrolidine is vital for advancing pharmaceutical research and development. By focusing on purity, application relevance, and supplier reliability, procurement professionals can ensure their projects proceed smoothly and efficiently.