For professionals in the pharmaceutical industry, securing high-quality chemical compounds is paramount. One such critical compound is (S)-(-)-Norverapamil Hydrochloride, a metabolite of the well-known drug Verapamil. Understanding its role and how to source it effectively can significantly impact research and development timelines and outcomes. This article serves as a guide for procurement managers and researchers looking to buy (S)-(-)-Norverapamil Hydrochloride.

What is (S)-(-)-Norverapamil Hydrochloride?

(S)-(-)-Norverapamil Hydrochloride (CAS 147158-72-3) is recognized as a significant metabolite of Verapamil. Verapamil itself is a calcium channel blocker used to treat hypertension, angina, and cardiac arrhythmias. As a metabolite, Norverapamil plays a role in the body's processing of Verapamil, and its precise identification and quantification are vital for understanding drug efficacy, safety, and pharmacokinetic profiles. This makes it an indispensable component in drug metabolism studies and as an analytical reference standard.

Why is High Purity Essential?

In pharmaceutical research and development, purity is not just a desirable attribute; it is a necessity. Using a high-purity (S)-(-)-Norverapamil Hydrochloride ensures that experimental results are accurate and reproducible. Impurities can lead to misleading data, affecting drug efficacy studies, safety assessments, and regulatory compliance. Researchers and formulation scientists rely on suppliers who can guarantee consistent purity levels for reference materials and intermediates, making the choice of supplier critical.

Key Applications in Pharmaceutical R&D

  • Drug Metabolism Studies: Researchers use this compound to study how Verapamil is metabolized in the body, which is crucial for developing optimal dosing regimens and predicting potential drug interactions.
  • Analytical Reference Standard: As a reference standard, it's used in quality control laboratories to identify and quantify the presence of Norverapamil in biological samples or pharmaceutical formulations.
  • Impurity Profiling: In the synthesis of Verapamil or related compounds, Norverapamil can sometimes appear as an impurity. Having a pure standard allows for accurate detection and control of these impurities.
  • Pharmacokinetic and Pharmacodynamic (PK/PD) Studies: Understanding how a drug is absorbed, distributed, metabolized, and excreted (PK), and its effects on the body (PD), relies heavily on the availability of such reference materials.

Finding a Reliable Manufacturer and Supplier

When looking to purchase (S)-(-)-Norverapamil Hydrochloride, it's important to identify manufacturers and suppliers who specialize in pharmaceutical intermediates and reference standards. Key factors to consider include:

  • Certifications and Quality Control: Look for suppliers with robust quality management systems and certifications, such as ISO. A comprehensive Certificate of Analysis (CoA) detailing purity, identity, and testing methods is essential.
  • Manufacturing Capabilities: A reputable manufacturer will have the expertise and facilities for synthesizing complex molecules like Norverapamil Hydrochloride with high precision.
  • Customer Support and Lead Times: Reliable suppliers offer excellent customer service and transparent information regarding lead times and shipping. Sourcing from a supplier in China can often provide cost advantages, but it's crucial to vet them thoroughly for quality and reliability.
  • Product Availability: Ensuring consistent availability is key for ongoing research projects. Check if the supplier offers bulk quantities or custom synthesis options if needed.

For those in need of this vital pharmaceutical intermediate, NINGBO INNO PHARMCHEM CO.,LTD. stands as a dedicated manufacturer and supplier, committed to providing high-purity (S)-(-)-Norverapamil Hydrochloride to meet the rigorous demands of the pharmaceutical industry. We invite you to request a quote or sample to experience our commitment to quality and service.