In the realm of chemical synthesis, particularly for pharmaceutical applications, precise specifications for raw materials are non-negotiable. 4-Ethyl-5-fluoropyrimidine (CAS: 137234-88-9) is a compound that requires meticulous attention to detail regarding its purity, physical characteristics, and handling. For researchers and production managers alike, understanding these specifications is key to ensuring successful synthesis, particularly in the development of critical drugs like Voriconazole.

Key Chemical Properties and Identification:

4-Ethyl-5-fluoropyrimidine is characterized by its unique molecular structure, which includes an ethyl group and a fluorine atom attached to a pyrimidine ring. Its chemical formula is C6H7FN2, with a molecular weight of 126.13 g/mol. The CAS number, 137234-88-9, serves as its universal identifier in chemical databases and regulatory filings. Reputable manufacturers often provide additional identifiers such as MDL numbers (e.g., MFCD06657566) and SMILES notations (e.g., CCC1=NC=NC=C1F) for unambiguous identification.

Purity: The Critical Factor for Pharmaceutical Intermediates

The purity of 4-Ethyl-5-fluoropyrimidine is perhaps its most critical specification, especially when it's used as an intermediate in pharmaceutical manufacturing. Typically, this compound is supplied with a purity level of 97% or higher, often verified by analytical techniques such as Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC). For R&D chemists, even minor impurities can influence reaction outcomes or lead to the formation of unwanted by-products. For production managers, maintaining batch-to-batch consistency in purity is essential for meeting regulatory standards and ensuring the quality of the final Active Pharmaceutical Ingredient (API).

Appearance and Physical State:

The physical appearance of 4-Ethyl-5-fluoropyrimidine is generally described as a colorless to light yellow liquid. While seemingly a minor detail, the appearance can sometimes be an initial indicator of product quality or potential degradation, although it's crucial to rely on analytical data for definitive quality assessment. Storage conditions, often recommended as +5°C or room temperature depending on the supplier's formulation, are also vital for maintaining its integrity.

Applications and Sourcing Considerations:

As a key intermediate for Voriconazole synthesis and other fine chemical applications, understanding the specifications helps in determining the suitability of a particular supplier's product. When you need to buy 4-Ethyl-5-fluoropyrimidine for your synthesis projects, always:

  • Request a Certificate of Analysis (CoA): This document provides lot-specific details on purity, identification, and other relevant analytical data.
  • Compare Specifications: Different manufacturers might have slightly varied specifications. Ensure they meet your project's exact requirements.
  • Inquire about Manufacturing Processes: Understanding the synthesis route can offer insights into potential impurities and the supplier's quality control measures.
  • Seek Bulk Quotes: For production scales, direct communication with manufacturers or their authorized distributors is recommended to get accurate pricing and delivery schedules.

By meticulously reviewing and understanding the specifications of 4-Ethyl-5-fluoropyrimidine, scientists and procurement professionals can make informed decisions, ensuring the reliable sourcing of this crucial chemical building block for their critical synthesis needs.