When selecting chemical intermediates for synthesis, understanding their precise specifications is critical for achieving desired results. 3-Ethoxyacryloyl chloride (CAS: 6191-99-7) is no exception. This article outlines the key specifications that guide its use, particularly in pharmaceutical manufacturing.

The primary specification for 3-Ethoxyacryloyl chloride is its purity, typically stated as greater than 98.0% as determined by High-Performance Liquid Chromatography (HPLC). This high purity is essential, especially when it is used as an intermediate for Active Pharmaceutical Ingredients (APIs) like Dasatinib, where even minor impurities can impact the final product's quality and regulatory compliance.

The appearance of the chemical is also a key indicator of its quality and consistency. 3-Ethoxyacryloyl chloride is described as a clear, colorless liquid. Any deviation from this description might suggest contamination or degradation.

Other important chemical and physical properties that manufacturers provide include:

  • CAS Number: 6191-99-7, a crucial identifier for procurement and regulatory purposes.
  • Molecular Formula: C5H7ClO2.
  • Molecular Weight: 134.56 g/mol.
  • Boiling Point: 171.8°C at 760 mmHg, indicating its volatility and handling requirements.
  • Density: 1.125 g/cm³.
  • Flash Point: 62.1°C, relevant for safety considerations during handling and storage.
  • Moisture Content: Typically specified as ≤1%, as water can react with acyl chlorides, affecting purity and reactivity.

These specifications collectively ensure that 3-Ethoxyacryloyl chloride is suitable for its intended applications, particularly in the demanding field of pharmaceutical synthesis. By carefully reviewing and adhering to these quality parameters, researchers and manufacturers can confidently integrate this chemical into their processes, ensuring reliable and high-quality outcomes.