For professionals in the pharmaceutical and fine chemical industries, a deep understanding of chemical specifications is fundamental to successful sourcing and manufacturing. Diethyl 1,1-Cyclobutanedicarboxylate (CAS 3779-29-1), a key intermediate, is no exception. Its physical and chemical properties, coupled with purity standards, dictate its suitability for specific applications, most notably in the synthesis of Carboplatin.

The primary specification to consider when sourcing Diethyl 1,1-Cyclobutanedicarboxylate is its purity, typically expressed as an assay percentage. For most pharmaceutical applications, an assay of ≥99.0% is considered standard. This high level of purity ensures that the chemical performs predictably in synthesis reactions, minimizing the risk of unwanted side reactions or the formation of impurities that could compromise the final Active Pharmaceutical Ingredient (API). Manufacturers often provide a detailed Certificate of Analysis (CoA) with each batch, outlining the assay results and other critical parameters.

Another important specification is the moisture content. Diethyl 1,1-Cyclobutanedicarboxylate is usually specified with a maximum moisture content of ≤0.2%. Excessive moisture can interfere with chemical reactions, particularly those involving moisture-sensitive reagents, and can also impact the stability of the material over time. Proper handling and storage, as indicated by suppliers, are crucial to maintaining low moisture levels.

Physical characteristics are also specified, such as its appearance. Diethyl 1,1-Cyclobutanedicarboxylate is consistently described as a colorless transparent liquid. This visual inspection is a basic but important check for quality, as any deviation in color or clarity might indicate contamination or degradation.

Other physical properties, like boiling point (e.g., 104-105°C at 12 mm Hg) and refractive index (around 1.4360), are often provided. While these might seem like highly technical details, they serve as benchmarks for confirming the identity and quality of the material. For R&D scientists, understanding these properties can also be beneficial for process design and analytical method development.

When you are looking to buy Diethyl 1,1-Cyclobutanedicarboxylate, prioritize suppliers who are transparent about these specifications and can consistently meet them. Working with a trusted manufacturer or distributor in China or globally ensures you receive a product that meets the demanding standards of the pharmaceutical industry, facilitating your research and production goals.