For procurement managers and R&D scientists involved in organic synthesis, understanding the detailed specifications of chemical intermediates is fundamental to successful project outcomes. These specifications dictate the suitability of a compound for a particular reaction and ultimately impact the purity and yield of the final product. This article explores the key specifications of organic synthesis intermediates, highlighting the importance of elements like CAS number, purity, appearance, and density, using a complex methyl ester (CAS 274693-25-3) as a case study.

The Chemical Abstracts Service (CAS) registry number, such as 274693-25-3, is the universal identifier for a specific chemical substance. It removes ambiguity and ensures that all parties involved in the transaction are referring to the exact same compound. When you search for this methyl ester, the CAS number is your first and most critical point of reference. Knowing this number allows you to effectively communicate your needs to potential manufacturers and suppliers.

Purity is arguably the most critical specification for any chemical intermediate, especially in sensitive applications like pharmaceutical synthesis. A purity level of 98% for our methyl ester signifies that the bulk material consists of at least 98% of the desired compound, with the remaining 2% being impurities. The nature and quantity of these impurities are often detailed in the Certificate of Analysis (CoA) provided by the manufacturer. For R&D scientists aiming for high yields and precise reactions, a higher purity level is generally preferred, and actively seeking to buy such high-purity materials is a standard practice.

Appearance and physical state provide immediate visual cues about the compound's characteristics. Our methyl ester is described as a white or light yellow crystalline powder. This description helps procurement managers confirm they are receiving the correct product and can also offer initial indications of quality. Variations in color or physical form might suggest degradation or contamination. When sourcing from a Chinese supplier, understanding these descriptions is vital for a visual quality check upon receipt.

Density, such as the 1.57±0.1 g/cm³ for this specific methyl ester, is another important physical parameter. It is relevant for calculations involving volume and mass, particularly in process design and scale-up. For instance, when a manufacturer quotes a price per kilogram, understanding the density helps in estimating the volume required for a specific batch size. This parameter also contributes to the overall characterization of the compound and can be an indicator of its crystalline structure.

In conclusion, a comprehensive understanding of these specifications is indispensable for anyone involved in the procurement and use of organic synthesis intermediates. The CAS number, purity, appearance, and density are not just technical details; they are the foundation upon which successful chemical synthesis is built. By diligently reviewing these specifications and engaging with reputable manufacturers and suppliers who provide accurate documentation, businesses can ensure they are purchasing the right materials for their critical applications.