For professionals in the chemical and pharmaceutical industries, understanding the precise properties and application potential of key reagents is fundamental. 2-Methoxyethoxymethyl chloride (CAS 3970-21-6) is one such compound, valued for its unique chemical characteristics and its critical role in various synthetic processes. This article provides a closer look at its specifications and utility.

Key Chemical Properties and Specifications
2-Methoxyethoxymethyl chloride is typically characterized as a liquid with a clear, colorless to yellow appearance. Its molecular formula is C4H9ClO2, with a molecular weight of approximately 124.57 g/mol. Crucially, it boasts a high purity level, often specified as ≥95.0% by GC analysis, which is essential for reliable reactions. Other important properties include:

  • Boiling Point: 50-52 °C at 13 mmHg.
  • Density: Approximately 1.091 g/mL at 25°C.
  • Refractive Index: n20/D 1.427.
  • Flash Point: Greater than 230°F (>110°C).

These specifications are vital for chemists and engineers when designing reaction conditions, ensuring safe handling, and predicting product yield and purity, especially when used as a roxithromycin intermediate or for introducing protecting groups.

Applications in Organic Synthesis
The primary application of 2-Methoxyethoxymethyl chloride in organic synthesis is as a reagent for introducing the methoxyethoxy ether (MEM) protecting group onto alcohols. The MEM group is favored for its relative stability and the diverse methods available for its removal, often using acidic conditions. This makes it a valuable tool in multi-step syntheses where selective protection and deprotection are required. Researchers looking to buy this compound will find it indispensable for complex molecular constructions.

Importance in Pharmaceutical Manufacturing
Beyond its general use as a protecting agent, 2-Methoxyethoxymethyl chloride plays a specific and significant role as an intermediate in the synthesis of roxithromycin, a widely used antibiotic. The consistent supply of high-purity material from reliable manufacturers is crucial for pharmaceutical companies to maintain production schedules and meet regulatory requirements. For those needing to purchase this component, understanding its role in API synthesis is key.

Sourcing and Quality Assurance
When seeking to procure 2-Methoxyethoxymethyl chloride, it is imperative to partner with reputable chemical suppliers. Companies that provide detailed product information, offer competitive price quotes, and maintain stringent quality control measures ensure that the material meets the necessary standards. Many leading global suppliers are based in China, offering excellent value and consistent availability for this specialty chemical.

In essence, the detailed properties of 2-Methoxyethoxymethyl chloride highlight its importance as a versatile reagent in chemical synthesis. Whether for its role as a protecting group or as a key roxithromycin intermediate, sourcing this compound from trusted manufacturers ensures the quality and efficiency of your chemical processes. If you are looking to buy, consider inquiring about our offerings.