Cancer research is a dynamic field constantly seeking novel therapeutic targets and the molecular tools to study them. Among the most promising targets is the process of angiogenesis, the formation of new blood vessels that tumors rely on for growth and survival. Vascular Endothelial Growth Factor Receptors (VEGFRs) are central to this process, and inhibitors of these receptors have become vital in cancer research. One such compound, SU 5416 (CAS 204005-46-9), offers researchers a powerful means to explore these complex signaling pathways.

The Molecular Mechanism of SU 5416

SU 5416 is a small molecule inhibitor that primarily targets Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), also known as Flk-1 or KDR. When VEGF binds to VEGFR2 on the surface of endothelial cells, it triggers a cascade of intracellular events, including the phosphorylation of tyrosine residues on the receptor and downstream signaling proteins like ERK (Extracellular signal-regulated kinase). This activation promotes endothelial cell proliferation, migration, and survival, leading to the formation of new blood vessels. SU 5416 works by competitively inhibiting the tyrosine kinase activity of VEGFR2, thereby blocking these pro-angiogenic signals. This disruption can effectively slow or halt tumor growth by limiting its blood supply.

Beyond its primary target, SU 5416 has also been shown to inhibit other receptor tyrosine kinases, such as KIT, RET, MET, and FLT3. This broader inhibitory profile makes it a versatile compound for investigating multiple signaling pathways implicated in cancer and other diseases.

Impact on Cancer Cell Signaling and Research Applications

By modulating VEGFR signaling, SU 5416 has a direct impact on cancer cell biology:

  • Inhibition of Tumor Growth: By starving tumors of necessary nutrients and oxygen, SU 5416 can significantly slow tumor progression.
  • Anti-metastatic Effects: Targeting angiogenesis can also limit the ability of cancer cells to invade surrounding tissues and metastasize to distant sites.
  • Research into Signaling Pathways: Its ability to inhibit multiple kinases makes it a valuable tool for dissecting complex cellular communication networks.

For researchers, obtaining high-quality SU 5416 is crucial for obtaining reliable data. As a leading manufacturer and supplier of fine chemicals in China, we provide SU 5416 with guaranteed purity and specifications, ensuring its effectiveness in your experimental setups. Our commitment to quality means you can confidently buy SU 5416 for your cancer research, drug discovery efforts, or studies on angiogenesis.

Procuring SU 5416 for Your Lab

When seeking to purchase SU 5416, partnering with a reputable supplier is essential. We offer a consistent and dependable supply of this critical research compound. Our streamlined processes ensure efficient procurement, competitive pricing, and thorough quality control, meeting the demanding standards of scientific research. If you require a high-purity VEGFR inhibitor for your studies, we encourage you to inquire about our product offerings and discover how we can support your laboratory needs.

In summary, SU 5416 is a pivotal small molecule that aids researchers in understanding and combating angiogenesis-driven diseases, particularly cancer. Its well-defined mechanism of action and broad applicability make it an indispensable tool in the modern research laboratory.