In the intricate world of pharmaceutical synthesis, the identification and reliable sourcing of critical intermediates are paramount. For those involved in the development and manufacturing of Tolvaptan, the compound 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one, identified by CAS number 137977-97-0, is an indispensable component. This article aims to guide procurement specialists and R&D scientists in finding a trustworthy supplier for this vital pharmaceutical intermediate.

What is 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one?

This chemical intermediate, often referred to as Tolvaptan Intermediate, is a white to off-white solid with the molecular formula C18H17ClN2O2. Its primary role is as a precursor in the synthesis of Tolvaptan, a medication used to manage hyponatremia. The quality and purity of this intermediate directly impact the success of the downstream synthesis of the Active Pharmaceutical Ingredient (API).

Key Requirements for a Supplier

When seeking a supplier for CAS 137977-97-0, consider these essential attributes:

  • Manufacturing Expertise: A supplier should possess strong chemical synthesis capabilities and a deep understanding of producing pharmaceutical intermediates that meet high-purity standards.
  • Quality Assurance Systems: Robust quality control measures, adherence to pharmacopoeial standards (USP, BP, EP), and comprehensive documentation (COA, MSDS) are non-negotiable.
  • Reliable Supply Chain: Consistent availability and timely delivery are crucial for uninterrupted production schedules. Look for suppliers with stable manufacturing operations and efficient logistics.
  • Technical Support: Access to technical expertise for product application and troubleshooting can be invaluable.
  • Competitive Pricing: While quality is paramount, securing the material at a reasonable price point is essential for cost management.

NINGBO INNO PHARMCHEM CO.,LTD. is a premier manufacturer and supplier dedicated to meeting these exacting requirements. We specialize in producing high-quality pharmaceutical intermediates, including 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one (CAS 137977-97-0). Our commitment to quality control and supply chain efficiency ensures that our clients receive reliable materials for their critical synthesis needs.

How to Procure This Intermediate

To initiate the procurement process, it is advisable to directly contact manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. Submit an inquiry detailing your specific needs, including:

  • Required quantity (e.g., kilograms, metric tons)
  • Purity specifications
  • Packaging preferences
  • Delivery timeline and location

This information will allow us to provide you with a precise quotation and detailed product information. We are equipped to handle both R&D scale orders and large commercial batch purchases.

Conclusion

Securing a consistent and high-quality supply of 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one (CAS 137977-97-0) is vital for successful Tolvaptan manufacturing. By partnering with experienced and quality-focused suppliers such as NINGBO INNO PHARMCHEM CO.,LTD., pharmaceutical companies can ensure the integrity of their production processes and the efficacy of their final products. We encourage you to reach out to us with your inquiries and experience our commitment to excellence in pharmaceutical intermediate supply.