In the highly regulated pharmaceutical industry, the consistent availability of high-quality raw materials and intermediates is non-negotiable. For manufacturers of Moxifloxacin, a widely used fluoroquinolone antibiotic, the procurement of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid (CAS: 112811-72-0) is a critical operational step. This article provides insight into the supplier landscape and what pharmaceutical professionals should prioritize when looking to buy this essential compound.

Key Intermediate: Properties and Significance

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid (C14H11F2NO4, MW ~295.24 g/mol) is characterized by its white to off-white crystalline powder appearance. Its high purity, typically exceeding 99%, is essential for its role as a direct precursor in the synthesis of Moxifloxacin and its hydrochloride salt. The chemical’s specific structural features are integral to the antibiotic's pharmacological activity, making quality control of utmost importance.

Selecting a Reliable Supplier for Pharmaceutical Intermediates

When engaging in the procurement of such specialized chemicals, identifying a trustworthy supplier is paramount. Pharmaceutical companies must consider several key criteria:

  • Quality Assurance: A supplier must demonstrate robust quality control systems, providing detailed Certificates of Analysis (CoAs) that confirm purity (e.g., ≥98.5% assay), impurity profiles, and compliance with specifications.
  • Manufacturing Capabilities: Does the manufacturer have sufficient production capacity to meet demand, and do they operate under appropriate quality management systems? Many reliable sources are located in China, known for their chemical manufacturing expertise.
  • Regulatory Compliance: For pharmaceutical applications, suppliers who can provide documentation such as DMFs or adhere to GMP principles (even if not directly GMP certified for intermediates, adherence to quality standards is key) are highly valued.
  • Technical Support and Responsiveness: A supplier should offer accessible technical expertise and prompt responses to inquiries, aiding in smooth integration into your manufacturing processes.
  • Competitive Pricing: While quality is primary, obtaining competitive pricing is crucial for cost-effective drug production. Always request a quote for your specific order volume.

As a seasoned manufacturer and supplier, we specialize in providing high-purity pharmaceutical intermediates like 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid. Our commitment to quality and reliable supply chain management ensures that our clients receive materials that meet the rigorous demands of pharmaceutical synthesis. We encourage all procurement professionals and R&D scientists to connect with us for a quote and explore how we can be your trusted partner in sourcing critical chemical building blocks.