Suzuki Coupling Fundamentals: Leveraging 4-Aminophenylboronic Acid for C-C Bond Formation
The ability to form carbon-carbon bonds with precision and efficiency is a cornerstone of modern organic synthesis, enabling the creation of everything from life-saving pharmaceuticals to advanced materials. Among the most powerful tools for achieving this is the Suzuki-Miyaura cross-coupling reaction, a process that has revolutionized how chemists construct complex organic molecules. Central to the success of this reaction is the availability of high-quality boronic acids or their derivatives, such as 4-aminophenylboronic acid (CAS 89415-43-0).
The Suzuki coupling involves the palladium-catalyzed reaction between an organoboron compound (like a boronic acid or ester) and an organohalide or pseudohalide. This reaction is celebrated for its mild conditions, high functional group tolerance, and the ability to create highly specific C-C bonds. 4-Aminophenylboronic acid, with its readily reactive boronic acid group, serves as an excellent organoboron partner. The presence of the amine functionality on the same molecule adds further versatility, allowing for subsequent modifications or incorporation into larger structures.
For chemists involved in R&D, selecting the right boronic acid is crucial for reaction success. 4-Aminophenylboronic acid, typically available as a solid with a purity of 97% or higher, provides the reliability needed for consistent results. Whether you are synthesizing pharmaceutical intermediates, OLED materials, or custom organic compounds, the quality of your starting materials directly impacts the outcome. This is why many researchers choose to buy from established manufacturers who guarantee product specifications. Suppliers in China are particularly noted for their capabilities in producing such fine chemical intermediates at competitive price points.
When embarking on a synthesis project that requires C-C bond formation, understanding the nuances of Suzuki coupling and having access to dependable reagents is key. 4-Aminophenylboronic acid offers a robust solution for introducing an aniline moiety attached to a phenyl ring via a stable C-C bond. For procurement managers and research scientists alike, identifying a trustworthy manufacturer that can supply this chemical consistently and at a fair price is a strategic imperative. Exploring the offerings from leading Chinese chemical suppliers will often reveal excellent options for sourcing this essential coupling reagent, thereby streamlining your synthetic endeavors.
Perspectives & Insights
Molecule Vision 7
“For chemists involved in R&D, selecting the right boronic acid is crucial for reaction success.”
Alpha Origin 24
“4-Aminophenylboronic acid, typically available as a solid with a purity of 97% or higher, provides the reliability needed for consistent results.”
Future Analyst X
“Whether you are synthesizing pharmaceutical intermediates, OLED materials, or custom organic compounds, the quality of your starting materials directly impacts the outcome.”