The Suzuki-Miyaura coupling reaction stands as a cornerstone of modern organic synthesis, revolutionizing the way chemists construct carbon-carbon bonds. This palladium-catalyzed cross-coupling reaction is particularly renowned for its versatility, mild reaction conditions, and tolerance of a wide range of functional groups. At the heart of many successful Suzuki couplings lies the availability of high-quality organoboron compounds, with aryl boronic acids being exceptionally important. Among these, 4-Biphenylboronic acid (CAS 5122-94-1) plays a pivotal role.

4-Biphenylboronic acid, often appearing as a white powder, is a key intermediate used to introduce the biphenyl moiety into target molecules. This structural unit is prevalent in many pharmaceuticals, agrochemicals, and advanced materials such as liquid crystals and organic light-emitting diodes (OLEDs). Its utility in Suzuki coupling allows for the efficient synthesis of complex biaryl systems, which are often challenging to prepare through traditional methods. When searching to buy 4-biphenylboronic acid, ensuring its purity and suitability for catalysis is paramount.

The synthesis of 4-Biphenylboronic acid itself typically involves the lithiation of 4-bromobiphenyl followed by quenching with a borate ester, such as trimethyl borate or triisopropyl borate, and subsequent hydrolysis. Manufacturers specializing in aryl boronic acids often optimize these processes to achieve high yields and purity, typically ≥98.0%. For chemists and procurement specialists, understanding these synthetic routes can offer insight into the potential impurity profiles and the rigorous quality control measures required.

The demand for 4-Biphenylboronic acid is driven by its widespread application. In the pharmaceutical sector, it serves as an intermediate for numerous drug candidates. In materials science, its incorporation into conjugated systems can tailor electronic and optical properties. For any of these applications, sourcing from a reliable manufacturer, particularly one based in China known for its chemical production capabilities, is often the most strategic approach. These suppliers can offer competitive pricing and ensure consistent product quality, which is essential for reproducible results in Suzuki couplings.

When sourcing 4-Biphenylboronic acid, it is advisable to request detailed specifications and a Certificate of Analysis (CoA) from potential suppliers. Key parameters to look for include the assay percentage, water content, and the absence of specific detrimental impurities that could interfere with catalytic activity. Building a relationship with a manufacturer that prioritizes quality control and offers excellent customer support, including timely quotes and samples, will significantly streamline your procurement process.

We are a dedicated manufacturer and supplier of high-quality 4-Biphenylboronic acid in China, committed to supporting your research and production needs. Whether you are optimizing a Suzuki coupling or developing novel materials, our product is engineered for excellence. Contact us today to discuss your requirements and obtain a competitive quote for 4-biphenylboronic acid.