3-Pyridylacetic Acid Hydrochloride (CAS 6419-36-9) stands as a significant compound within the fine chemical and pharmaceutical industries. Its precise molecular architecture and reactivity make it an indispensable intermediate, most notably in the synthesis of Risedronate Sodium. Understanding its chemical nature, how it's produced, and its primary applications is crucial for researchers, formulators, and procurement specialists looking to buy this high-value chemical.

Chemical Profile and Properties

Characterized by its molecular formula C7H8ClNO2 and a molecular weight of approximately 173.6 g/mol, 3-Pyridylacetic Acid Hydrochloride typically presents as an off-white to beige crystalline powder. It possesses a melting point in the range of 161-163 °C, indicating a stable solid form under ambient conditions. Its stability under normal temperatures and pressures, coupled with its high purity (often ≥99.0% assay), makes it a reliable raw material for sensitive chemical reactions. Solubility in solvents like DMSO and methanol is noted, further aiding its use in various synthetic procedures.

Synthesis Pathways for 3-Pyridylacetic Acid Hydrochloride

The production of 3-Pyridylacetic Acid Hydrochloride involves multi-step organic synthesis. A common route often starts from precursor molecules like 2-chloropyridine-3-acetic acid. The process typically involves reactions such as catalytic hydrogenation, neutralization, decolorization with activated carbon, salt formation with hydrochloric acid, and meticulous purification steps. The goal is always to achieve a high yield of the desired product with minimal impurities, ensuring it meets the strict purity requirements for pharmaceutical use. This detailed synthesis process highlights the expertise required from a chemical manufacturer and the value proposition when you purchase from a reliable supplier.

Primary Application: The Cornerstone of Risedronate Sodium

The most prominent application for 3-Pyridylacetic Acid Hydrochloride is its role as a key intermediate in the manufacturing of Risedronate Sodium. Risedronate Sodium is a bisphosphonate drug that inhibits osteoclast activity, thereby reducing bone resorption and is widely prescribed for the treatment of osteoporosis, Paget's disease of bone, and other bone-related disorders. The reliable availability of high-quality 3-Pyridylacetic Acid Hydrochloride directly impacts the production capacity and efficacy of this vital medication. For pharmaceutical companies, securing this intermediate from an experienced manufacturer in China is often a strategic move.

Beyond Risedronate: Other Potential Uses

While Risedronate Sodium synthesis is the primary driver for its demand, the versatile pyridineacetic acid structure also makes it a valuable building block in broader organic synthesis. It can be employed in the development of other pharmaceutical agents, agrochemicals, or specialty materials. Researchers may find its utility in medicinal chemistry for creating novel pyridine-based compounds with potential therapeutic activities. If you are looking to buy this compound for research or specialized synthesis, ensure you are sourcing from a manufacturer that can provide detailed specifications and certificates of analysis.

In conclusion, 3-Pyridylacetic Acid Hydrochloride is more than just a chemical compound; it is a critical enabler of modern pharmaceutical treatments. Its synthesis and applications underscore the importance of specialized chemical manufacturing and the strategic advantages of sourcing from global suppliers like those in China who prioritize purity and reliability.