For chemists engaged in advanced organic synthesis and pharmaceutical research, understanding the properties and synthetic routes of key intermediates is fundamental. 2-(Methylthio)phenyl Isothiocyanate, identified by CAS 51333-75-6, is a compound of significant interest due to its reactive nature and role as a versatile building block. As a leading manufacturer and supplier of fine chemicals and pharmaceutical intermediates, we provide insights into this compound's chemistry and its importance in the industry.

Chemical Profile of 2-(Methylthio)phenyl Isothiocyanate

This organic compound features a phenyl ring substituted with a methylthio group and an isothiocyanate (-NCS) group. Its chemical formula is C8H7NS2, and it has a molecular weight of 181.28 g/mol. The presence of the isothiocyanate group makes it highly reactive towards nucleophiles, making it an excellent precursor for synthesizing heterocycles, thioureas, and other sulfur- and nitrogen-containing compounds. The methylthio substituent influences its electronic properties and can participate in further chemical transformations.

Key physical properties include a boiling point of 149-150 °C at 10 mmHg, indicating moderate volatility. It is typically supplied with a high purity of 99.5%min, which is critical for its use as a pharmaceutical intermediate. This high purity ensures that subsequent reactions proceed efficiently and that the final products meet stringent quality standards, a crucial aspect for anyone looking to buy this chemical for research or production.

Synthetic Pathways and Reactivity

The synthesis of isothiocyanates generally involves the reaction of primary amines with carbon disulfide followed by treatment with reagents like phosgene or its equivalents, or through thiocarbamoyl chlorides. While specific industrial synthesis routes for 2-(Methylthio)phenyl Isothiocyanate may vary, it is commonly derived from the corresponding aniline derivative, 2-(methylthio)aniline. The reactivity of the isothiocyanate group allows it to undergo various reactions, including:

  • Nucleophilic Addition: Reaction with amines to form thioureas.
  • Cyclization Reactions: Formation of heterocyclic compounds like thiazoles or thiadiazoles when reacted with appropriate bifunctional nucleophiles.
  • Reaction with Alcohols: Formation of thiocarbamates.

These reactions underscore its utility as a building block in creating diverse molecular structures relevant to drug discovery and material science.

Why Partner with a Reliable Supplier?

For researchers and procurement specialists, sourcing 2-(Methylthio)phenyl Isothiocyanate requires attention to detail regarding purity, consistency, and availability. As a primary supplier in China, we understand the importance of providing high-quality chemicals with reliable technical support. When you purchase this intermediate, consider the benefits of working with a direct manufacturer who can offer competitive price points and ensure timely delivery. This is especially important for those scaling up production.

In essence, 2-(Methylthio)phenyl Isothiocyanate is a valuable intermediate for chemists. Its well-defined chemical properties and reactivity make it a staple in many synthetic strategies. By partnering with a trusted supplier, researchers and manufacturers can confidently integrate this compound into their processes, ensuring efficiency and quality in their final products.