N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide (CAS 90357-53-2) is a significant molecule within the realm of organic synthesis, particularly valued as a pharmaceutical intermediate. Its intricate structure, featuring a trifluoromethyl group and a cyano moiety on a phenyl ring, coupled with a methacrylamide functional group, endows it with unique reactivity, making it a sought-after compound for researchers and manufacturers alike. Understanding its synthesis and application is key for professionals looking to buy this specialized chemical.

The synthesis of N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide typically involves the reaction of 4-amino-2-(trifluoromethyl)benzonitrile with methacryloyl chloride. This acylation reaction, often carried out under controlled conditions with a suitable base and solvent, yields the desired product with high efficiency. The availability of high-quality starting materials, such as 4-amino-2-(trifluoromethyl)benzonitrile, is crucial for the success of this synthesis. Manufacturers who can reliably produce this intermediate must have robust process control and purification techniques to ensure a high-purity final product, often exceeding 98% purity via GC analysis.

The primary application of N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide lies in its role as a critical intermediate in the synthesis of pharmaceuticals. Its structure makes it an ideal precursor for building complex molecules. For instance, it is a key component in the manufacturing pathway for Bicalutamide, a non-steroidal antiandrogen used in the treatment of prostate cancer. This specific application highlights the importance of procuring this intermediate from trusted suppliers who understand the stringent requirements of the pharmaceutical industry.

Beyond its role in Bicalutamide synthesis, this compound can also serve as a versatile building block in other areas of chemical research. Its reactive functional groups allow for further modifications, enabling the creation of novel compounds with potentially useful properties in materials science or agrochemicals. Researchers exploring new synthetic methodologies or developing novel chemical entities often look to buy such well-defined intermediates.

For businesses and research institutions looking to purchase N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide, it is advisable to source from reputable manufacturers in China or globally that specialize in fine chemicals. These suppliers can offer competitive pricing and guaranteed quality, essential for R&D projects and commercial production. We pride ourselves on being a reliable manufacturer and supplier, ensuring that you can buy this important intermediate with confidence, supported by comprehensive product data and excellent customer service.