2-(2-Chlorophenyl)-2-hydroxyacetonitrile (CAS: 13312-84-0) stands out as a crucial intermediate in modern chemical synthesis, prized for its functional groups that enable a wide array of transformations. As a dedicated manufacturer and supplier of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. understands the intricate requirements of researchers and formulators who depend on reliable access to such compounds. This article delves into its synthesis and significant applications.

The typical synthesis of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile involves the nucleophilic addition of a cyanide source to 2-chlorobenzaldehyde under controlled basic conditions. This reaction, often carried out in polar aprotic solvents, requires careful management of temperature and reagent stoichiometry to optimize yield and minimize side products. For instance, maintaining specific temperature ranges, often around room temperature or slightly elevated, and using appropriate bases like sodium hydroxide or potassium carbonate are key to achieving good conversion. Understanding these parameters is vital for anyone looking to synthesize or source this compound.

The compound's molecular structure, featuring an ortho-chlorophenyl ring, a hydroxyl group, and a nitrile moiety, dictates its reactivity and broad applicability. The nitrile group is amenable to hydrolysis, reduction to amines, or participation in cycloaddition reactions. The hydroxyl group can undergo esterification or etherification. The presence of the chlorine atom on the phenyl ring also opens avenues for various substitution or cross-coupling reactions.

In the pharmaceutical sector, 2-(2-Chlorophenyl)-2-hydroxyacetonitrile serves as a valuable building block for synthesizing Active Pharmaceutical Ingredients (APIs). Its structure is a precursor to important motifs found in beta-blockers and antifungal agents, underscoring its importance in drug discovery and development. Researchers often seek to buy this intermediate for its versatility in constructing complex molecular architectures.

Beyond pharmaceuticals, the compound finds significant use in the agrochemical industry. It acts as an intermediate in the production of pesticides and other crop protection agents. The ability to tailor its structure through further reactions makes it an attractive component for developing new, more effective agrochemical formulations.

For businesses looking to purchase 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, NINGBO INNO PHARMCHEM CO.,LTD. offers a consistent supply of high-purity material. Our expertise as a chemical intermediate manufacturer ensures that you receive a product that meets your exacting standards, supporting your research and manufacturing endeavors. Whether you are a formulator or a researcher, understanding the synthesis and application of this compound is key to leveraging its full potential.