In the vast realm of chemical intermediates, certain compounds distinguish themselves through their versatility and broad applicability. 4-Bromo-2-methoxypyridine (CAS: 100367-39-3) is one such molecule, serving as a critical building block in numerous synthetic pathways, particularly in the fields of organic synthesis and pharmaceutical research. This deep dive explores its synthesis, key applications, and the importance of sourcing it reliably from chemical manufacturers.

The chemical structure of 4-Bromo-2-methoxypyridine features a pyridine ring functionalized with a bromine atom at the 4-position and a methoxy group at the 2-position. This specific arrangement imparts distinct reactivity, making it a valuable synthon for introducing complex pyridine motifs into larger molecules. The presence of the bromine atom makes it an excellent substrate for various palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling, which is fundamental for forming carbon-carbon bonds. This capability allows chemists to efficiently build sophisticated molecular architectures required for novel pharmaceuticals, agrochemicals, and advanced materials.

The synthesis of 4-Bromo-2-methoxypyridine typically involves established organic chemistry techniques. One common method is the regioselective bromination of 2-methoxypyridine. Researchers often employ reagents like N-bromosuccinimide (NBS) under controlled conditions to achieve the desired substitution pattern. Alternatively, functional group interconversions or directed metalation strategies can be utilized. The pursuit of efficient and green synthetic routes is an ongoing effort in the chemical industry, aiming to optimize yields and minimize environmental impact. When looking to buy this intermediate, understanding the typical purity levels (often ≥99.0%) is crucial for ensuring the success of downstream reactions.

The applications of 4-Bromo-2-methoxypyridine are widespread. In pharmaceutical research, it serves as a key intermediate for synthesizing numerous drug candidates. It is particularly instrumental in the preparation of imidazo[1,2-a]pyrimidines and various substituted pyridones, both of which are scaffolds found in many commercially available drugs and those under development for treating diseases ranging from cancer to infections. Its utility also extends to agrochemical research, where it acts as a building block for creating new pesticides and herbicides. For those involved in these fields, identifying a reliable supplier that offers consistent quality and competitive price is paramount.

Procurement professionals and researchers often turn to specialized chemical suppliers for their needs. When searching for 4-Bromo-2-methoxypyridine, noting the CAS number (100367-39-3) and verifying the purity specifications are standard practices. The physical form (typically a light yellow solid) and solubility characteristics are also important for laboratory handling and reaction design.

In conclusion, 4-Bromo-2-methoxypyridine is a cornerstone intermediate in modern chemical synthesis. Its versatility, driven by its unique structure and reactivity, makes it an invaluable tool for drug discovery, agrochemical development, and materials science. By understanding its synthetic pathways and applications, and by securing a dependable supply from qualified manufacturers, researchers and industries can effectively leverage this compound to drive innovation and achieve their project goals.