In the realm of synthetic chemistry, certain molecular structures stand out for their versatility and importance in creating advanced materials and therapeutics. The fluorinated pyrimidine derivative, 4-Chloro-6-Ethyl-5-Fluoropyrimidine (CAS 137234-74-3), is one such compound, serving as a critical intermediate in both the pharmaceutical and agrochemical industries. Understanding its synthesis, properties, and applications is crucial for researchers and procurement specialists aiming to leverage its potential.

Chemical Profile and Properties
4-Chloro-6-Ethyl-5-Fluoropyrimidine is characterized by its pyrimidine ring substituted with a chlorine atom, an ethyl group, and a fluorine atom. This specific arrangement of functional groups provides reactive sites that are highly valuable for further chemical transformations. Typically supplied as a white to off-white crystalline powder, it exhibits good solubility in common organic solvents and requires specific storage conditions, often at 2-8°C, to maintain its stability. Its purity, often exceeding 98% by HPLC, is a key indicator of its suitability for demanding applications.

Synthesis Pathways and Manufacturing
The synthesis of 4-Chloro-6-Ethyl-5-Fluoropyrimidine generally involves multi-step organic reactions, often starting from readily available pyrimidine precursors. A common route might involve chlorination and fluorination steps, requiring precise control of reaction conditions and reagents. Manufacturers specializing in fine chemicals and pharmaceutical intermediates, such as those with significant production capacities (e.g., 200 tons/month), are equipped to produce this compound efficiently and at scale. The expertise of a dedicated manufacturer is vital for ensuring consistent quality and yield.

Crucial Applications in Key Industries
The primary utility of 4-Chloro-6-Ethyl-5-Fluoropyrimidine lies in its role as a pharmaceutical intermediate. It is a vital building block for synthesizing important drugs, including:

  • Anticancer Agents: Used in the synthesis of molecules targeting cancer cell proliferation.
  • Antiviral Therapies: Essential for creating nucleoside analogs and other antiviral compounds.
  • Kinase Inhibitors: Facilitates the development of targeted therapies for various diseases.

Beyond pharmaceuticals, this intermediate also finds application in agrochemical research, where its unique structure can be utilized to develop novel pesticides with improved efficacy and environmental profiles. Its reactivity makes it suitable for exploring diverse heterocyclic chemistry.

Sourcing Strategies for Buyers
When seeking to buy 4-Chloro-6-Ethyl-5-Fluoropyrimidine, it is imperative to partner with reputable manufacturers and suppliers. Prioritize vendors who offer high purity, consistent quality, competitive pricing, and a stable supply chain. Companies that specialize in advanced intermediates and have robust manufacturing capabilities, like many established suppliers in China, are ideal partners for both R&D and commercial production needs. We are committed to being your trusted source for this indispensable chemical intermediate.