The field of organic chemistry constantly seeks novel compounds and efficient pathways to synthesize them, driving innovation in pharmaceuticals, materials science, and beyond. 6-Methyleneandrost-4-ene-3,17-dione (CAS 19457-55-7) is one such compound that garners significant attention due to its unique steroidal structure and its role as a versatile intermediate. Its molecular formula, C20H26O2, and molecular weight of 298.42, hint at its complex structure and potential reactivity.

The synthesis of 6-Methyleneandrost-4-ene-3,17-dione typically involves modifying the androstenedione backbone. A common method described in literature involves the reaction of androst-4-ene-3,17-dione with formaldehyde, often under acidic catalysis. For instance, using reagents like triethyl orthoformate and p-toluenesulfonic acid, followed by treatment with formaldehyde and HCl, can yield the desired product. This synthetic route highlights the controlled chemical transformations required to introduce the methylene group at the 6-position of the steroid ring. The resulting compound's physical form is usually a pale yellow solid, with specific melting points and densities documented by manufacturers and in chemical databases.

The applications of 6-Methyleneandrost-4-ene-3,17-dione are primarily centered within the pharmaceutical and research sectors. Its steroid framework makes it an excellent precursor for the synthesis of various steroid-based drugs, including those used in hormonal therapy. It is also recognized as a key related compound or impurity in the manufacturing process of drugs like Exemestane. Therefore, access to high-purity 6-Methyleneandrost-4-ene-3,17-dione is essential for pharmaceutical companies conducting quality control and impurity profiling. Researchers also utilize it as a chemical building block in exploring new molecular entities.

For those looking to procure this compound, understanding its synthesis and applications allows for more informed purchasing decisions. Buyers should seek out manufacturers who not only produce the chemical consistently but also provide detailed specifications and safety data. When considering where to purchase CAS 19457-55-7, it is beneficial to look for suppliers in regions known for their robust chemical manufacturing capabilities, such as China, where competitive pricing and large-scale production are often available. Ensuring you purchase from a reliable supplier guarantees the quality and suitability of this crucial intermediate for your intended use.