Exploring the Synthesis of Cilastatin: The Role of Ethyl 7-Chloro-2-Oxoheptanoate
Cilastatin is a vital pharmaceutical compound, primarily known for its role in enhancing the efficacy of the antibiotic Imipenem. It functions as a dehydropeptidase inhibitor, preventing the metabolic breakdown of Imipenem in the kidneys, thereby prolonging its therapeutic action and broadening its antibacterial spectrum. The synthesis of Cilastatin is a complex chemical process that relies on specific intermediate compounds, with Ethyl 7-Chloro-2-Oxoheptanoate (CAS: 78834-75-0) playing a crucial role.
Understanding the chemical properties of Ethyl 7-Chloro-2-Oxoheptanoate is key to appreciating its function in Cilastatin synthesis. This alpha-keto ester, with its molecular formula C9H15ClO3, presents as a clear yellow liquid. Its structure, featuring both a chlorine atom and a keto-ester group, provides the necessary reactivity for the subsequent steps in Cilastatin production. For pharmaceutical researchers and manufacturers looking to buy Ethyl 7-Chloro-2-Oxoheptanoate, ensuring high purity is paramount, as impurities can affect the yield and quality of the final Cilastatin product.
As a dedicated pharmaceutical intermediate manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides Ethyl 7-Chloro-2-Oxoheptanoate that is specifically optimized for pharmaceutical synthesis. Our commitment to quality means that the intermediates we supply are rigorously tested to meet the stringent requirements of drug manufacturing. We understand that the reliable availability of such intermediates at a competitive price is critical for our clients. Therefore, we focus on efficient production processes and a robust supply chain to serve as a dependable supplier.
The synthesis pathway typically involves reacting Ethyl 7-Chloro-2-Oxoheptanoate with other chiral building blocks to construct the complex structure of Cilastatin. The precise stereochemistry and functional groups present in the intermediate are essential for achieving the desired biological activity. When sourcing this compound, it is advisable to partner with a reputable supplier in China that can guarantee consistent quality and supply. Our expertise in fine chemicals allows us to support your synthetic chemistry needs effectively.
In conclusion, Ethyl 7-Chloro-2-Oxoheptanoate is an indispensable component in the production of Cilastatin, a critical drug for treating severe bacterial infections. Its chemical characteristics make it an ideal starting material for complex pharmaceutical synthesis. If your organization requires this vital intermediate, we encourage you to contact NINGBO INNO PHARMCHEM CO.,LTD., your trusted chemical raw material supplier, to discuss your specific requirements and obtain a quotation.
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Chem Reader AI
“Cilastatin is a vital pharmaceutical compound, primarily known for its role in enhancing the efficacy of the antibiotic Imipenem.”
Agile Vision 2025
“It functions as a dehydropeptidase inhibitor, preventing the metabolic breakdown of Imipenem in the kidneys, thereby prolonging its therapeutic action and broadening its antibacterial spectrum.”