The Synthesis Journey: From 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]ethanone to Iloperidone
The creation of modern pharmaceuticals often involves multi-step synthetic processes, where each intermediate plays a distinct and crucial role. For the antipsychotic drug Iloperidone, 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (CAS 58113-30-7) serves as a pivotal precursor. NINGBO INNO PHARMCHEM CO.,LTD. actively participates in this journey by supplying this high-quality intermediate.
The synthesis of Iloperidone typically involves the N-alkylation of a piperidine derivative with 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone. This reaction is a key step in assembling the final molecular structure of the drug. The purity and reactivity of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone are critical for the success of this step, directly influencing the overall yield and the impurity profile of the resulting Iloperidone. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. focus on producing this intermediate with exceptional assay results (≥98.0% by HPLC) to facilitate smooth and efficient subsequent reactions.
While various synthetic routes for Iloperidone have been explored and patented, the consistent quality of intermediates remains a constant requirement. The compound's chemical properties, such as the reactive chloropropoxy group, are leveraged in these synthetic pathways. The fine chemical industry, particularly in China, has advanced significantly in optimizing the production of such intermediates, ensuring that they meet the demanding specifications required for pharmaceutical applications.
NINGBO INNO PHARMCHEM CO.,LTD. contributes to this progress by adhering to strict quality control measures throughout the manufacturing process of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone. This dedication ensures that our clients receive a product that is not only chemically precise but also consistently available, supporting the continuous production of Iloperidone. Our role as a supplier is to facilitate the reliable synthesis of vital medicines.
By providing an intermediate with a reliable purity profile and carefully managed physical characteristics, NINGBO INNO PHARMCHEM CO.,LTD. empowers pharmaceutical companies to focus on the latter stages of drug synthesis and formulation. The journey from raw materials to finished pharmaceuticals is complex, and the quality of intermediates like 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone is a testament to the advancements in chemical manufacturing.
Perspectives & Insights
Chem Catalyst Pro
“This dedication ensures that our clients receive a product that is not only chemically precise but also consistently available, supporting the continuous production of Iloperidone.”
Agile Thinker 7
“Our role as a supplier is to facilitate the reliable synthesis of vital medicines.”
Logic Spark 24
“By providing an intermediate with a reliable purity profile and carefully managed physical characteristics, NINGBO INNO PHARMCHEM CO.”