The development of life-saving medications relies heavily on the precise synthesis of complex molecules. For the antiarrhythmic drug Dofetilide, a critical intermediate plays a pivotal role in its manufacturing pathway: N-Acetyl-2-(4-Nitrophenyl)ethylamine, identified by CAS number 6270-07-1. Understanding the synthesis of this intermediate, its properties, and its importance in the overall production of Dofetilide is vital for chemists, researchers, and procurement specialists in the pharmaceutical industry.

Understanding Dofetilide and its Need

Dofetilide is a Class III antiarrhythmic agent used to treat certain types of irregular heartbeats. Its efficacy and safety profile necessitate a highly controlled and pure manufacturing process. The quality of the starting materials and intermediates directly impacts the final API's purity and effectiveness. Therefore, sourcing reliable and high-specification N-Acetyl-2-(4-Nitrophenyl)ethylamine is a fundamental step in the Dofetilide production chain.

The Chemical Journey: From Intermediate to API

While specific synthesis routes can vary and are often proprietary, the general pathway for Dofetilide involves using N-Acetyl-2-(4-Nitrophenyl)ethylamine as a precursor. This intermediate, characterized by its nitro group and acetamide functionalization, provides a key structural element that is further modified. The synthesis typically involves reduction of the nitro group and subsequent reactions to build the final Dofetilide molecule. The typical light yellow powder form of N-Acetyl-2-(4-Nitrophenyl)ethylamine with a purity of ≥98.0% ensures that the subsequent reactions proceed efficiently and with minimal by-product formation.

Sourcing High-Quality N-Acetyl-2-(4-Nitrophenyl)ethylamine

For pharmaceutical manufacturers, finding a dependable supplier for CAS 6270-07-1 is crucial. Key considerations include:

  • Purity and Consistency: A consistent assay of ≥98.0% and reliable batch-to-batch quality are essential for reproducible synthesis.
  • Supplier Reliability: Partnering with experienced manufacturers, especially those based in China known for competitive chemical supply, can secure your supply chain.
  • Technical Specifications: Access to detailed product information, including CoAs and SDS, is necessary for R&D and safety protocols.
  • Competitive Pricing: Obtaining this intermediate at a favorable price point allows for cost-effective production of Dofetilide.

Partnering for Success with NINGBO INNO PHARMCHEM CO.,LTD.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier dedicated to providing critical pharmaceutical intermediates like N-Acetyl-2-(4-Nitrophenyl)ethylamine (CAS 6270-07-1). We understand the importance of quality and reliability in drug synthesis. If your organization requires this key intermediate for Dofetilide production or other organic synthesis applications, we encourage you to contact us. We are equipped to meet your needs for high-purity chemicals and to serve as your trusted partner from laboratory scale to commercial production.