The field of organic chemistry thrives on the development and utilization of versatile building blocks. Among these, 4-Ethyl-2-pyridinamine (CAS: 33252-32-3) has emerged as a compound of significant interest due to its unique structure and reactivity. As a pyridine derivative, it offers a reactive amine group and an ethyl substituent, making it an invaluable intermediate for chemists aiming to synthesize advanced organic compounds. This article explores the synthetic pathways and applications where 4-Ethyl-2-pyridinamine proves indispensable.

The Chemical Profile of 4-Ethyl-2-pyridinamine

Characterized as a white crystalline powder, 4-Ethyl-2-pyridinamine (MF: C7H10N2) is readily handled in laboratory settings. Its key physical properties, such as a melting point of 50-52°C, coupled with its chemical structure, allow for a wide range of transformations. The presence of the pyridine ring imparts aromaticity and basicity, while the amine group at the 2-position offers a site for nucleophilic reactions, amide formation, and further functionalization. The ethyl group at the 4-position influences its electronic and steric properties, which can be critical in directing reaction selectivity and final product characteristics.

Key Synthetic Applications

The utility of 4-Ethyl-2-pyridinamine as a synthon is well-documented in various research areas:

  • Pharmaceutical Intermediates: One of the most prominent uses is in the synthesis of pharmaceutical compounds. It serves as a precursor for molecules analogous to pirlimycin, an antibiotic, and is also used in the preparation of more complex drug candidates. Researchers often buy this compound to build intricate molecular architectures for drug discovery programs.
  • Heterocyclic Chemistry: The pyridine core makes it an excellent starting material for constructing fused ring systems or modifying existing heterocyclic structures. Reactions involving the amine group can lead to the formation of new nitrogen-containing heterocycles, vital in medicinal chemistry.
  • Material Science: While less documented, pyridine derivatives can find applications in material science, potentially as ligands in coordination chemistry or as building blocks for functional polymers. Exploring its use in these areas often requires sourcing high-purity grades.
  • Agrochemicals: Similar to pharmaceuticals, the pyridine scaffold is common in many agrochemical compounds. 4-Ethyl-2-pyridinamine can be a key intermediate in developing new pesticides or herbicides.

Procurement and Quality Assurance

For researchers and chemical manufacturers, securing a reliable supply of 4-Ethyl-2-pyridinamine is crucial. When looking to purchase this compound, it is advisable to partner with established chemical suppliers who can guarantee high purity (often 99% min) and provide comprehensive analytical data. Manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., are known for their capabilities in producing and supplying such intermediates consistently. Obtaining a price quote for your specific quantity needs ensures cost-effectiveness for your synthetic projects.

The versatility of 4-Ethyl-2-pyridinamine makes it a sought-after intermediate in the pursuit of novel chemical entities. By understanding its synthetic potential and ensuring a reliable sourcing strategy, chemists can effectively leverage this compound to drive innovation in pharmaceutical, agrochemical, and material science fields.