For chemists and formulators, a deep understanding of a chemical intermediate's synthesis and properties is fundamental to its successful application. 3,4-Difluorobenzonitrile (CAS 64248-62-0) is a compound of significant interest due to its utility in pharmaceuticals, agrochemicals, and advanced materials. This article explores its synthesis routes and key physicochemical characteristics.

Synthesis Pathways of 3,4-Difluorobenzonitrile

While multiple synthesis routes can be employed, a common method involves the conversion of a precursor such as 3,4-difluorobenzamide. A typical process might involve reacting the amide with a dehydrating agent or catalyst system under controlled conditions. For instance, employing reagents like dichlorosulfoxide with a catalyst such as DMF in a suitable solvent like dichloroethane at elevated temperatures can yield the desired benzonitrile. Subsequent purification, often through distillation, is critical to achieving the high purity required for its applications.

The efficient synthesis of 3,4-Difluorobenzonitrile is a testament to modern organic chemistry techniques. Manufacturers continuously optimize these processes to ensure high yields, purity, and cost-effectiveness. Understanding the synthesis process helps buyers appreciate the quality and value they receive when purchasing from reputable suppliers.

Physicochemical Properties of 3,4-Difluorobenzonitrile

The physical and chemical properties of 3,4-Difluorobenzonitrile dictate its handling, storage, and reactivity:

  • Appearance: Typically presented as a white to light yellow crystalline powder or solid lump.
  • Molecular Formula: C7H3F2N.
  • Molecular Weight: Approximately 139.10 g/mol.
  • Melting Point: Generally reported in the range of 48-54 °C, indicating it is a solid at room temperature.
  • Boiling Point: Around 180 °C, signifying moderate volatility.
  • Solubility: Soluble in common organic solvents like methanol, DCM, and THF, but generally insoluble in water.
  • Purity: High purity grades, often exceeding 99.5%, are readily available from specialized chemical manufacturers and suppliers.

These properties make 3,4-Difluorobenzonitrile a manageable intermediate for various chemical processes. Its solid form simplifies handling and weighing compared to liquids, while its solubility in organic solvents allows for seamless integration into reaction mixtures.

For companies seeking to buy 3,4-Difluorobenzonitrile with guaranteed purity and reliable specifications, engaging with experienced manufacturers is essential. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this critical intermediate, backed by robust quality control and technical expertise. Contact us to learn more about our product and its specifications, and to secure a consistent supply for your synthesis needs.