For chemists and procurement managers in the B2B sector, a thorough understanding of chemical intermediates is crucial for successful product development and manufacturing. This article focuses on 3-Bromo-4-methylpyridine (CAS 3430-22-6), a compound widely recognized for its role in advanced synthesis. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. offers insights into its synthesis, properties, and applications, emphasizing why it's a valuable addition to your chemical inventory.

Synthesis Pathways for 3-Bromo-4-methylpyridine

The production of 3-Bromo-4-methylpyridine typically involves specific chemical reactions designed to introduce a bromine atom at the desired position on the 4-methylpyridine ring. One common method involves the bromination of 4-methylpyridine. A general procedure might include reacting 4-methylpyridine with a brominating agent, often in the presence of a catalyst and under controlled temperature conditions. For example, reacting 4-methylpyridine with bromine at elevated temperatures (around 120°C) with catalysts like aluminum chloride (AlCl3) and potassium bromide (KBr) can yield the target compound. Following the reaction, purification steps such as column chromatography are employed to achieve high purity, often exceeding 98% or 99%. The yield can vary, but efficient synthesis routes are critical for cost-effectiveness, which is a key consideration when sourcing from a manufacturer. Understanding these synthesis processes highlights the technical expertise required, reinforcing the value of purchasing from experienced chemical suppliers.

Key Chemical and Physical Properties

The utility of 3-Bromo-4-methylpyridine is directly linked to its distinct properties. Its appearance as a colorless to light yellow transparent liquid is standard. Key physical constants include a boiling point of 199-200 °C and a density of approximately 1.549 g/mL at 25 °C. The refractive index is typically around 1.56. Its solubility in common organic solvents like chloroform and methanol further enhances its applicability in various reaction media. For safe handling and storage, it is classified as an irritant (H315, H319, H335) and requires storage in a cool, dry, well-ventilated area, kept in a tightly closed container, away from light and heat sources. These properties are meticulously controlled and documented by reputable suppliers to ensure product integrity and user safety.

Importance as a Chemical Intermediate

As an intermediate, 3-Bromo-4-methylpyridine is indispensable for creating more complex molecules. Its strategic placement of functional groups allows chemists to perform regioselective reactions, which is crucial for constructing specific molecular architectures. This compound is a vital precursor in the synthesis of numerous high-value chemicals, including active pharmaceutical ingredients (APIs) and advanced agrochemicals. For instance, its role in the synthesis of proton pump inhibitors and PDE4 inhibitors makes it a sought-after material in the pharmaceutical sector. When you buy this intermediate, you are investing in a reliable foundation for your research and development pipelines. NINGBO INNO PHARMCHEM CO.,LTD. is your trusted source in China for this essential chemical, offering competitive pricing and assured quality for your procurement needs.

We are committed to providing the chemical industry with high-quality intermediates. For inquiries about pricing, bulk orders, or technical specifications for 3-Bromo-4-methylpyridine, please contact NINGBO INNO PHARMCHEM CO.,LTD.