For researchers and chemists engaged in the synthesis of complex organic molecules, a thorough understanding of intermediate compounds is essential. 4-Chloro-3-(trifluoromethyl)aniline, identified by CAS number 320-51-4, is one such critical intermediate, prized for its role in constructing advanced pharmaceuticals and agrochemicals. Delving into its synthesis and properties provides valuable insights for R&D professionals.

The synthesis of 4-Chloro-3-(trifluoromethyl)aniline typically involves the reduction of a nitro precursor. A common pathway involves starting with 2-chloro-5-nitrobenzotrifluoride. This precursor can be reacted using various reducing agents and conditions, such as catalytic hydrogenation or chemical reduction (e.g., using iron in acidic media or sodium borohydride with metal catalysts). For instance, a reported method utilizes Fe nanoparticles and NaBH4 in a TPGS/H2O solution, yielding the desired aniline derivative in high percentage yield and purity.

The chemical and physical properties of this compound are largely dictated by its structure. It typically appears as a white to pinkish or slightly orange crystalline powder or a low melting solid, with a melting point range of 35-37 °C. Its molecular formula is C7H5ClF3N, and its molecular weight is approximately 195.57 g/mol. The compound exhibits limited solubility in water but is soluble in common organic solvents like methanol and chloroform. The presence of the electron-withdrawing trifluoromethyl and chlorine groups significantly influences its reactivity, particularly on the aromatic ring and the amine functional group.

Spectroscopic data, such as 1H NMR and 13C NMR, are crucial for confirming its structure and purity. The proton NMR spectrum, for example, would show distinct signals corresponding to the aromatic protons and the amine protons, providing a fingerprint for identification. Understanding these properties is key for formulators and scientists who need to ensure compatibility and reactivity in their specific applications.

For those looking to buy 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine for their research or manufacturing needs, engaging with experienced chemical suppliers is vital. A reliable manufacturer will provide detailed technical specifications, including synthesis routes and purity analysis, to support your project goals. As a dedicated supplier, we offer high-quality CAS 320-51-4 and are equipped to provide the technical data you need to integrate it effectively into your synthesis workflows.