For chemists and researchers engaged in organic synthesis, a thorough understanding of intermediate compounds is vital. 4-Chloropyridine-2-carbonitrile (CAS: 19235-89-3) is a pyridine derivative that has garnered significant attention due to its utility as a versatile building block. This article aims to provide insights into its synthesis pathways and key chemical and physical properties, enabling professionals to make informed decisions when procuring this essential intermediate.

The synthesis of 4-Chloropyridine-2-carbonitrile often begins with readily available pyridine precursors. Several routes have been documented in chemical literature and patents. One common approach involves the conversion of 4-chloro-2-methylpyridine. This can be achieved through a multi-step process where the methyl group is oxidized to a carboxylic acid, followed by conversion to an amide and subsequent dehydration to yield the nitrile. Alternatively, diazotization of 2-amino-4-chloropyridine, followed by reaction with a cyanide source like cuprous cyanide, presents another viable synthesis route. The choice of method often depends on factors such as raw material availability, cost, desired purity, and the scale of production. When you buy 4-Chloropyridine-2-carbonitrile, understanding its synthetic origin can provide assurance regarding its impurity profile.

Physically, 4-Chloropyridine-2-carbonitrile is typically described as an off-white to pale yellow crystalline powder. Its molecular formula is C6H3ClN2, and it possesses a molecular weight of approximately 138.55 g/mol. Key physical properties, such as a melting point range of 81-85°C and a boiling point around 231.6°C, are important parameters for handling, purification, and reaction design. Its solubility characteristics are also noteworthy; it exhibits good solubility in common organic solvents like dichloromethane and chloroform, but limited solubility in water. This differential solubility is often exploited during work-up and purification procedures.

Chemically, the presence of the electron-withdrawing nitrile group and the chlorine atom on the pyridine ring significantly influences its reactivity. The chlorine atom can undergo nucleophilic substitution, while the nitrile group can participate in various addition and cyclization reactions. These reactive sites make it an ideal starting material for building more complex heterocyclic structures, essential in the synthesis of pharmaceuticals and agrochemicals. As a reputable manufacturer and supplier, we ensure our 4-Chloropyridine-2-carbonitrile meets the specifications required for these demanding applications.

For procurement professionals and research scientists, understanding these synthesis routes and properties is key to ensuring the successful integration of 4-Chloropyridine-2-carbonitrile into their projects. Whether you are looking to buy this intermediate for drug discovery, agrochemical development, or materials research, our commitment to quality and reliable supply from China ensures you receive a product that meets your exact needs. We welcome inquiries regarding its price, availability, and technical specifications.