For chemists, researchers, and procurement specialists in the chemical industry, a deep understanding of a compound's synthesis and properties is fundamental to its effective utilization. 4-Hydroxyphenylacetic Acid (CAS 156-38-7) is one such compound, a versatile organic intermediate with significant applications in pharmaceuticals, agrochemicals, and beyond. This article aims to provide a comprehensive overview of its synthesis pathways and critical properties.

4-Hydroxyphenylacetic Acid, a white to light tan crystalline powder, possesses the molecular formula C8H8O3 and a molecular weight of 152.15. Its melting point typically ranges from 148-151 °C, and it exhibits moderate solubility in water, being more soluble in solvents like ether, ethanol, and ethyl acetate. These physical characteristics are important for handling, formulation, and reaction design.

The synthesis of 4-Hydroxyphenylacetic Acid can be achieved through several methods. A common route involves the diazotization and hydrolysis of 4-aminophenylacetic acid. This process typically includes preparing the sodium salt of 4-aminophenylacetic acid, followed by controlled addition of sodium nitrate solution under specific temperature conditions. Subsequent hydrolysis of the diazonium salt at elevated temperatures, followed by purification steps like extraction and solvent recovery, yields the desired product. This method, while effective, is often accompanied by discussions around yield optimization and process efficiency, which are key concerns for chemical manufacturers looking to produce this compound at scale.

Alternative synthesis routes are also explored, including methods that utilize boron tribromide in dichloromethane for demethylation of methoxy-substituted precursors. The pursuit of greener and more sustainable synthesis methods, such as microbial biosynthesis using engineered E. coli strains, is also a growing area of research, aiming to reduce environmental impact and improve production efficiency. For businesses looking to buy 4-Hydroxyphenylacetic Acid, understanding the manufacturing process of their supplier can offer insights into product consistency and environmental responsibility.

As a supplier, we ensure that our 4-Hydroxyphenylacetic Acid is produced with meticulous attention to detail, adhering to industry best practices. The reliable supply of this compound is critical for industries that depend on it for the synthesis of pharmaceuticals and agrochemicals. We provide detailed technical specifications to assist R&D scientists in their work, and our competitive pricing makes us an attractive option for procurement managers seeking cost-effective solutions.

Whether you are developing new drug formulations or advancing agrochemical technologies, understanding the nuances of 4-Hydroxyphenylacetic Acid's synthesis and properties is invaluable. We invite you to partner with us for your supply needs, leveraging our expertise and commitment to quality.